4CN2

Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human Ramp2 Response Element

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008270	molecular_function	zinc ion binding
C	0043565	molecular_function	sequence-specific DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1211

Chain	Residue
C	CYS135
C	CYS138
C	CYS152
C	CYS155

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1212

Chain	Residue
C	CYS171
C	CYS177
C	CYS187
C	CYS190

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MES C 1213

Chain	Residue
C	ASP166
C	LEU167
C	THR168
C	TYR169
C	TYR189
C	TYR192
C	GLN193
C	ARG202
C	THR162

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1213

Chain	Residue
D	CYS135
D	CYS138
D	CYS152
D	CYS155

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1214

Chain	Residue
D	CYS171
D	CYS177
D	CYS187
D	CYS190

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 1215

Chain	Residue
D	ARG172
D	CYS187
D	GLN188

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 1214

Chain	Residue
C	VAL149
C	TYR150
D	HOH2025

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 1216

Chain	Residue
B	HOH2019
B	HOH2020
D	GLN206
D	ARG209

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 1217

Chain	Residue
D	TYR169
D	THR170
D	ARG186

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MG C 1215

Chain	Residue
B	DG11
B	DA12
C	ASP140
C	CYS152
C	GLU153
C	GLY154
C	ARG184
C	MG1217

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 1216

Chain	Residue
C	LEU196
C	GLY199
C	MET200
C	LYS201

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1035

Chain	Residue
A	DT1
A	DG2
A	HOH2039
C	GLY144
C	LYS145

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 1218

Chain	Residue
B	DT3
B	DG4
D	GLY154
D	PHE158
D	ARG161

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 1217

Chain	Residue
B	DA12
C	ASP140
C	LYS181
C	ARG184
C	MG1215
C	HOH2037

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1036

Chain	Residue
A	DG10
A	HOH2029
D	HIS146

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 1035

Chain	Residue
B	DT9
B	HOH2031
B	HOH2032
C	LYS165

---

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Drssgk.HYgvysCegCkgFFkR

Chain	Residue	Details
C	CYS135-ARG161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	DNA binding: {"description":"Nuclear receptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	88
Details	Zinc finger: {"description":"NR C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Region: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"12145331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10669605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BY4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; by EP300","evidences":[{"source":"PubMed","id":"17761950","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---