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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4CK7

Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in presence of adp.alfx (NECK-LINKER IN ITS DISCONNECTED CONFORMATION, based on cryo-electron microscopy experiment

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		TUBULIN ALPHA-1D CHAINpolymer45250236.41UniProt (Q2HJ86)
Pfam (PF00091)
Pfam (PF03953)		BOS TAURUS (CATTLE)ALPHA TUBULIN
2B
(B)		TUBULIN BETA-2B CHAINpolymer44549907.81UniProt (Q6B856)
Pfam (PF00091)
Pfam (PF03953)		BOS TAURUS (CATTLE)BETA TUBULIN
3C
(C)		KINESIN-LIKE PROTEIN KIF11polymer37341673.11UniProt (P52732)
Pfam (PF00225)		HOMO SAPIENS (HUMAN)KINESIN-LIKE PROTEIN 1, KINESIN-LIKE SPINDLE PROTEIN HKSP, KINESIN-RELATED MOTOR PROTEIN EG5, THYROID RECEPTOR-INTERACTING PROTEIN 5, TR-INTERACTING PROTEIN 5, TRIP-5, KINESIN-5
4D, H
(A, C)		MAGNESIUM IONnon-polymer24.32Chemie (MG)
PubChem (888)
5E
(A)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
PubChem (177679032)
PubChem (135400627)
PubChem (135487750)
PubChem (136088935)
PubChem (136803486)
PubChem (135398633)
PubChem (135544356)
PubChem (135547949)
PubChem (135600366)
PubChem (135749822)
PubChem (136005188)
PubChem (136073923)
PubChem (136240914)
PubChem (136664747)
PubChem (136772743)
PubChem (136772744)
PubChem (136803487)
PubChem (137286749)
PubChem (164715984)
PubChem (171699466)
6F
(B)		GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
PubChem (136073927)
PubChem (135398619)
PubChem (135402030)
PubChem (135431654)
PubChem (135566337)
PubChem (135760556)
PubChem (136026707)
PubChem (136053418)
PubChem (136663964)
PubChem (136664748)
PubChem (136759848)
PubChem (136759849)
PubChem (136759850)
PubChem (136836636)
PubChem (136847074)
PubChem (172898537)
7G
(B)		TAXOLnon-polymer853.91Chemie (TA1)
PubChem (16757828)
PubChem (16760674)
PubChem (4666)
PubChem (21458255)
PubChem (23307219)
PubChem (23412627)
PubChem (23636632)
PubChem (16760177)
PubChem (16742549)
PubChem (24848897)
PubChem (24867246)
PubChem (21733096)
PubChem (23307242)
PubChem (23307253)
PubChem (23307913)
PubChem (44323108)
PubChem (44356961)
PubChem (44403716)
PubChem (24754091)
PubChem (24207713)
PubChem (24791027)
PubChem (25200067)
PubChem (42613129)
PubChem (42620039)
PubChem (44155032)
PubChem (44276363)
PubChem (46781469)
PubChem (44279927)
PubChem (44335735)
PubChem (44291178)
PubChem (44328863)
PubChem (44342632)
PubChem (44356895)
PubChem (44378736)
PubChem (49868078)
PubChem (45489039)
PubChem (46782671)
PubChem (54259298)
PubChem (71209844)
PubChem (57908851)
PubChem (57946364)
PubChem (58803237)
PubChem (53313247)
PubChem (53298534)
PubChem (54259297)
PubChem (59844545)
PubChem (54259299)
PubChem (59904698)
PubChem (60123443)
PubChem (57489669)
PubChem (57999380)
PubChem (58460861)
PubChem (58777027)
PubChem (58798493)
PubChem (58596717)
PubChem (59048611)
PubChem (59042813)
PubChem (58877402)
PubChem (60005248)
PubChem (59873251)
PubChem (59914794)
PubChem (59919147)
PubChem (60123436)
PubChem (60011010)
PubChem (60147315)
PubChem (66795656)
PubChem (70943371)
PubChem (71096818)
PubChem (5460441)
PubChem (14060298)
PubChem (176586897)
PubChem (177678861)
PubChem (73759783)
PubChem (36314)
PubChem (60915)
PubChem (177409)
PubChem (184492)
PubChem (70801836)
PubChem (70842048)
PubChem (70848451)
PubChem (70856170)
PubChem (441276)
PubChem (9854162)
PubChem (73707502)
PubChem (73759704)
PubChem (9897470)
PubChem (10033513)
PubChem (10485732)
PubChem (11506104)
PubChem (89493063)
PubChem (11828953)
PubChem (89847578)
PubChem (90057663)
PubChem (91122402)
PubChem (14060299)
PubChem (14060304)
PubChem (14060306)
PubChem (14060309)
PubChem (15983941)
PubChem (91885464)
PubChem (5317123)
PubChem (5321715)
PubChem (101920282)
PubChem (5352019)
PubChem (121459571)
PubChem (122361554)
PubChem (101598423)
PubChem (6604028)
PubChem (6604616)
PubChem (6604814)
PubChem (6713921)
PubChem (6915727)
PubChem (124747272)
PubChem (124893098)
PubChem (9875988)
PubChem (126968948)
PubChem (129395998)
PubChem (129627423)
PubChem (10748131)
PubChem (132517454)
PubChem (118528174)
PubChem (11320430)
PubChem (11354895)
PubChem (134368714)
PubChem (134972678)
PubChem (124747271)
PubChem (124747273)
PubChem (124747274)
PubChem (137705323)
PubChem (138106885)
PubChem (126761000)
PubChem (140731501)
PubChem (140512017)
PubChem (133052515)
PubChem (133640187)
PubChem (146034004)
PubChem (153289350)
PubChem (154037993)
PubChem (134715514)
PubChem (155982214)
PubChem (159121804)
PubChem (160053861)
PubChem (159716711)
PubChem (160171678)
PubChem (160585530)
PubChem (163077211)
PubChem (163077212)
PubChem (163077209)
PubChem (163284947)
PubChem (143890766)
PubChem (168322423)
PubChem (152743329)
PubChem (169917882)
PubChem (171036874)
PubChem (154828192)
PubChem (144453087)
PubChem (160585532)
PubChem (175758871)
PubChem (163077210)
PubChem (163077213)
PubChem (163077214)
PubChem (163077215)
PubChem (165084161)
PubChem (166711459)
PubChem (167423928)
PubChem (170014955)
PubChem (170362150)
8I
(C)		ALUMINUM FLUORIDEnon-polymer84.01Chemie (AF3)
PubChem (2124)
9J
(C)		ADENOSINE-5'-DIPHOSPHATEnon-polymer427.21Chemie (ADP)
Sequence modifications
A: 1 - 452 (UniProt: Q2HJ86)
PDBExternal DatabaseDetails
Ile 7Val 7conflict
Ile 114Leu 114conflict
Ser 136Leu 136conflict
Val 137Ile 137conflict
Gly 265Ile 265conflict
Glu 358Asp 358conflict
Val 437Met 437conflict
B: 1 - 445 (UniProt: Q6B856)
PDBExternal DatabaseDetails
Ala 55Thr 55conflict
Val 170Met 170conflict
Ala 296Ser 296conflict
Val 316Ile 316conflict
C: 1 - 367 (UniProt: P52732)
PDBExternal DatabaseDetails
Val 25Cys 25conflict
Ser 43Cys 43conflict
Ala 87Cys 87conflict
Ala 99Cys 99conflict
Cys 126Thr 126engineered mutation
His 368-expression tag
His 369-expression tag
His 370-expression tag
His 371-expression tag
His 372-expression tag
His 373-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight141817.2
Non-Polymers*Number of molecules7
Total formula weight2380.1
All*Total formula weight144197.3
*Water molecules are not included.

251422

PDB entries from 2026-04-01

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