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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4CK5

Pseudo-atomic model of microtubule-bound human kinesin-5 motor domain in the ADP state, based on cryo-electron microscopy experiment.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		TUBULIN ALPHA-1D CHAINpolymer45250236.41UniProt (Q2HJ86)
Pfam (PF00091)
Pfam (PF03953)		BOS TAURUS (CATTLE)ALPHA TUBULIN
2B
(B)		TUBULIN BETA-2B CHAINpolymer44549907.81UniProt (Q6B856)
Pfam (PF00091)
Pfam (PF03953)		BOS TAURUS (CATTLE)BETA TUBULIN
3C
(C)		KINESIN-LIKE PROTEIN KIF11polymer37341673.11UniProt (P52732)
Pfam (PF00225)		HOMO SAPIENS (HUMAN)KINESIN-LIKE PROTEIN 1, KINESIN-LIKE SPINDLE PROTEIN HKSP, KINESIN-RELATED MOTOR PROTEIN EG5, THYROID RECEPTOR-INTERACTING PR OTEIN 5, TR-INTERACTING PROTEIN 5, TRIP-5, KINESIN-5
4D
(A)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
PubChem (177679032)
PubChem (135400627)
PubChem (135487750)
PubChem (136088935)
PubChem (136803486)
PubChem (135398633)
PubChem (135544356)
PubChem (135547949)
PubChem (135600366)
PubChem (135749822)
PubChem (136005188)
PubChem (136073923)
PubChem (136240914)
PubChem (136664747)
PubChem (136772743)
PubChem (136772744)
PubChem (136803487)
PubChem (137286749)
PubChem (164715984)
PubChem (171699466)
5E
(B)		GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
PubChem (136073927)
PubChem (135398619)
PubChem (135402030)
PubChem (135431654)
PubChem (135566337)
PubChem (135760556)
PubChem (136026707)
PubChem (136053418)
PubChem (136663964)
PubChem (136664748)
PubChem (136759848)
PubChem (136759849)
PubChem (136759850)
PubChem (136836636)
PubChem (136847074)
PubChem (172898537)
6F
(B)		TAXOLnon-polymer853.91Chemie (TA1)
PubChem (16757828)
PubChem (16760674)
PubChem (4666)
PubChem (21458255)
PubChem (23307219)
PubChem (23412627)
PubChem (23636632)
PubChem (16760177)
PubChem (16742549)
PubChem (24848897)
PubChem (24867246)
PubChem (21733096)
PubChem (23307242)
PubChem (23307253)
PubChem (23307913)
PubChem (44323108)
PubChem (44356961)
PubChem (44403716)
PubChem (24754091)
PubChem (24207713)
PubChem (24791027)
PubChem (25200067)
PubChem (42613129)
PubChem (42620039)
PubChem (44155032)
PubChem (44276363)
PubChem (46781469)
PubChem (44279927)
PubChem (44335735)
PubChem (44291178)
PubChem (44328863)
PubChem (44342632)
PubChem (44356895)
PubChem (44378736)
PubChem (49868078)
PubChem (45489039)
PubChem (46782671)
PubChem (54259298)
PubChem (71209844)
PubChem (57908851)
PubChem (57946364)
PubChem (58803237)
PubChem (53313247)
PubChem (53298534)
PubChem (54259297)
PubChem (59844545)
PubChem (54259299)
PubChem (59904698)
PubChem (60123443)
PubChem (57489669)
PubChem (57999380)
PubChem (58460861)
PubChem (58777027)
PubChem (58798493)
PubChem (58596717)
PubChem (59048611)
PubChem (59042813)
PubChem (58877402)
PubChem (60005248)
PubChem (59873251)
PubChem (59914794)
PubChem (59919147)
PubChem (60123436)
PubChem (60011010)
PubChem (60147315)
PubChem (66795656)
PubChem (70943371)
PubChem (71096818)
PubChem (5460441)
PubChem (14060298)
PubChem (176586897)
PubChem (177678861)
PubChem (73759783)
PubChem (36314)
PubChem (60915)
PubChem (177409)
PubChem (184492)
PubChem (70801836)
PubChem (70842048)
PubChem (70848451)
PubChem (70856170)
PubChem (441276)
PubChem (9854162)
PubChem (73707502)
PubChem (73759704)
PubChem (9897470)
PubChem (10033513)
PubChem (10485732)
PubChem (11506104)
PubChem (89493063)
PubChem (11828953)
PubChem (89847578)
PubChem (90057663)
PubChem (91122402)
PubChem (14060299)
PubChem (14060304)
PubChem (14060306)
PubChem (14060309)
PubChem (15983941)
PubChem (91885464)
PubChem (5317123)
PubChem (5321715)
PubChem (101920282)
PubChem (5352019)
PubChem (121459571)
PubChem (122361554)
PubChem (101598423)
PubChem (6604028)
PubChem (6604616)
PubChem (6604814)
PubChem (6713921)
PubChem (6915727)
PubChem (124747272)
PubChem (124893098)
PubChem (9875988)
PubChem (126968948)
PubChem (129395998)
PubChem (129627423)
PubChem (10748131)
PubChem (132517454)
PubChem (118528174)
PubChem (11320430)
PubChem (11354895)
PubChem (134368714)
PubChem (134972678)
PubChem (124747271)
PubChem (124747273)
PubChem (124747274)
PubChem (137705323)
PubChem (138106885)
PubChem (126761000)
PubChem (140731501)
PubChem (140512017)
PubChem (133052515)
PubChem (133640187)
PubChem (146034004)
PubChem (153289350)
PubChem (154037993)
PubChem (134715514)
PubChem (155982214)
PubChem (159121804)
PubChem (160053861)
PubChem (159716711)
PubChem (160171678)
PubChem (160585530)
PubChem (163077211)
PubChem (163077212)
PubChem (163077209)
PubChem (163284947)
PubChem (143890766)
PubChem (168322423)
PubChem (152743329)
PubChem (169917882)
PubChem (171036874)
PubChem (154828192)
PubChem (144453087)
PubChem (160585532)
PubChem (175758871)
PubChem (163077210)
PubChem (163077213)
PubChem (163077214)
PubChem (163077215)
PubChem (165084161)
PubChem (166711459)
PubChem (167423928)
PubChem (170014955)
PubChem (170362150)
7G
(C)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
PubChem (888)
8H
(C)		ADENOSINE-5'-DIPHOSPHATEnon-polymer427.21Chemie (ADP)
Sequence modifications
A: 1 - 452 (UniProt: Q2HJ86)
PDBExternal DatabaseDetails
Ile 7Val 7conflict
Ile 114Leu 114conflict
Ser 136Leu 136conflict
Val 137Ile 137conflict
Glu 358Asp 358conflict
Val 437Met 437conflict
B: 1 - 445 (UniProt: Q6B856)
PDBExternal DatabaseDetails
Ala 55Thr 55conflict
Val 170Met 170conflict
Ala 296Ser 296conflict
Val 316Ile 316conflict
C: 1 - 360 (UniProt: P52732)
PDBExternal DatabaseDetails
Ser 43Cys 43engineered mutation
Ala 87Cys 87engineered mutation
Ala 99Cys 99engineered mutation
Cys 126Thr 126engineered mutation
His 361-expression tag
His 362-expression tag
His 363-expression tag
His 364-expression tag
His 365-expression tag
His 366-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight141817.2
Non-Polymers*Number of molecules5
Total formula weight2271.8
All*Total formula weight144089.0
*Water molecules are not included.

251422

PDB entries from 2026-04-01

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