4CFE
Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 | polymer | 571 | 64651.0 | 2 | UniProt (P54646) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) In PDB | HOMO SAPIENS (HUMAN) | AMPK SUBUNIT ALPHA-2, ACETYL-COA CARBOXYLASE KINASE, ACACA KINASE, HYDROXYMETHYLGLUTARYL-COA REDUCTASE KINASE, HMGCR KINASE |
2 | B, D | 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 | polymer | 286 | 32448.5 | 2 | UniProt (Q9Y478) Pfam (PF16561) Pfam (PF04739) In PDB | HOMO SAPIENS (HUMAN) | AMPK SUBUNIT BETA-1, AMPKB |
3 | E, F | 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 | polymer | 331 | 37626.3 | 2 | UniProt (P54619) Pfam (PF00571) In PDB | HOMO SAPIENS (HUMAN) | AMPK GAMMA1, AMPK SUBUNIT GAMMA-1, AMPKG |
4 | A, C | STAUROSPORINE | non-polymer | 466.5 | 2 | Chemie (STU) | |||
5 | A, C | 5-[[6-chloranyl-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy]-2-methyl-benzoic acid | non-polymer | 431.9 | 2 | Chemie (992) | |||
6 | E, F | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 6 | Chemie (AMP) | |||
7 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 552 (UniProt: P54646)
B, D: 1 - 270 (UniProt: Q9Y478)
PDB | External Database | Details |
---|---|---|
Met -18 | - | expression tag |
Ser -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Ser -10 | - | expression tag |
Ser -9 | - | expression tag |
Gly -8 | - | expression tag |
Leu -7 | - | expression tag |
Glu -6 | - | expression tag |
Val -5 | - | expression tag |
Leu -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Gly -1 | - | expression tag |
Pro 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -15 | - | expression tag |
Gly -14 | - | expression tag |
Leu -13 | - | expression tag |
Asn -12 | - | expression tag |
Asp -11 | - | expression tag |
Ile -10 | - | expression tag |
Phe -9 | - | expression tag |
Glu -8 | - | expression tag |
Ala -7 | - | expression tag |
Gln -6 | - | expression tag |
Lys -5 | - | expression tag |
Ile -4 | - | expression tag |
Glu -3 | - | expression tag |
Trp -2 | - | expression tag |
His -1 | - | expression tag |
Glu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 269451.4 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 3880.1 | |
All* | Total formula weight | 273331.6 |