4CFE
Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 | polymer | 571 | 64651.0 | 2 | UniProt (P54646) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) | HOMO SAPIENS (HUMAN) | AMPK SUBUNIT ALPHA-2, ACETYL-COA CARBOXYLASE KINASE, ACACA KINASE, HYDROXYMETHYLGLUTARYL-COA REDUCTASE KINASE, HMGCR KINASE |
| 2 | B, D (B, D) | 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 | polymer | 286 | 32448.5 | 2 | UniProt (Q9Y478) Pfam (PF16561) Pfam (PF04739) | HOMO SAPIENS (HUMAN) | AMPK SUBUNIT BETA-1, AMPKB |
| 3 | E, F (E, F) | 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 | polymer | 331 | 37626.3 | 2 | UniProt (P54619) Pfam (PF00571) | HOMO SAPIENS (HUMAN) | AMPK GAMMA1, AMPK SUBUNIT GAMMA-1, AMPKG |
| 4 | G, I (A, C) | STAUROSPORINE | non-polymer | 466.5 | 2 | Chemie (STU) PubChem (71203703) PubChem (42610657) PubChem (44299148) PubChem (49831000) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (358479) PubChem (5280487) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (68262703) PubChem (68306294) PubChem (73953205) PubChem (12046017) PubChem (86306248) PubChem (5279) PubChem (44259) PubChem (451705) PubChem (122130844) PubChem (5459111) PubChem (6419748) PubChem (9804568) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 5 | H, J (A, C) | 5-[[6-chloranyl-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy]-2-methyl-benzoic acid | non-polymer | 431.9 | 2 | Chemie (992) | |||
| 6 | K, L, M, N, O... (E, F) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 6 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (46875232) PubChem (177678969) PubChem (6083) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (1549371) PubChem (92144436) PubChem (224) PubChem (12358354) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (122197642) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 7 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 552 (UniProt: P54646)
B, D: 1 - 270 (UniProt: Q9Y478)
| PDB | External Database | Details |
|---|---|---|
| Met -18 | - | expression tag |
| Ser -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Leu -13 | - | expression tag |
| Asn -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Ile -10 | - | expression tag |
| Phe -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Gln -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Ile -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Trp -2 | - | expression tag |
| His -1 | - | expression tag |
| Glu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 269451.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3880.1 | |
| All* | Total formula weight | 273331.6 |
