4CFE
Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 | polymer | 571 | 64651.0 | 2 | UniProt (P54646) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) | HOMO SAPIENS (HUMAN) | AMPK SUBUNIT ALPHA-2, ACETYL-COA CARBOXYLASE KINASE, ACACA KINASE, HYDROXYMETHYLGLUTARYL-COA REDUCTASE KINASE, HMGCR KINASE |
| 2 | B, D (B, D) | 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 | polymer | 286 | 32448.5 | 2 | UniProt (Q9Y478) Pfam (PF16561) Pfam (PF04739) | HOMO SAPIENS (HUMAN) | AMPK SUBUNIT BETA-1, AMPKB |
| 3 | E, F (E, F) | 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 | polymer | 331 | 37626.3 | 2 | UniProt (P54619) Pfam (PF00571) | HOMO SAPIENS (HUMAN) | AMPK GAMMA1, AMPK SUBUNIT GAMMA-1, AMPKG |
| 4 | G, I (A, C) | STAUROSPORINE | non-polymer | 466.5 | 2 | Chemie (STU) | |||
| 5 | H, J (A, C) | 5-[[6-chloranyl-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy]-2-methyl-benzoic acid | non-polymer | 431.9 | 2 | Chemie (992) | |||
| 6 | K, L, M, N, O... (E, F) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 6 | Chemie (AMP) | |||
| 7 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 552 (UniProt: P54646)
B, D: 1 - 270 (UniProt: Q9Y478)
| PDB | External Database | Details |
|---|---|---|
| Met -18 | - | expression tag |
| Ser -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Leu -13 | - | expression tag |
| Asn -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Ile -10 | - | expression tag |
| Phe -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Gln -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Ile -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Trp -2 | - | expression tag |
| His -1 | - | expression tag |
| Glu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 269451.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3880.1 | |
| All* | Total formula weight | 273331.6 |
