4CCG

Structure of an E2-E3 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	UBIQUITIN-CONJUGATING ENZYME E2 T	polymer	212	24008.3	2	UniProt (Q9NPD8) Pfam (PF00179)	HOMO SAPIENS (HUMAN)	CELL PROLIFERATION-INDUCING GENE 50 PROTEIN, UBIQUITIN CARRIER PROTEIN T, UBIQUITIN-PROTEIN LIGASE T, FANCL RING E3 LIGASE AND UBE2T
2	C, D (X, Y)	E3 UBIQUITIN-PROTEIN LIGASE FANCL	polymer	88	10080.6	2	UniProt (Q9NW38) Pfam (PF11793)	HOMO SAPIENS (HUMAN)	FANCONI ANEMIA GROUP L PROTEIN, FANCONI ANEMIA-ASSOCIATED POLYPEPTIDE OF 43 KDA, FAAP43, FANCL RING E3 LIGASE AND UBE2T
3	E, F (A)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	2	Chemie (EPE)
4	G, H, K, O (A, B, X)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5	I, S (A, Y)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	J (B)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
7	L (B)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
8	M, N, Q, R (X, Y)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
9	P (X)	AMMONIUM ION	non-polymer		18.0	1	Chemie (NH4)
10	T, U, V, W (A, B, X, Y)	water	water		18.0	114	Chemie (HOH)

Sequence modifications

A, B: 1 - 197 (UniProt: Q9NPD8)

PDB	External Database	Details
Thr -14	-	expression tag
Gly -13	-	expression tag
Ser -12	-	expression tag
Thr -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
Thr -8	-	expression tag
Gly -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Thr -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	68177.8
Non-Polymers*	Number of molecules	15
	Total formula weight	1375.2
All*	Total formula weight	69553.1

*Water molecules are not included.