Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4CCG

Structure of an E2-E3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0003682	molecular_function	chromatin binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006281	biological_process	DNA repair
A	0006513	biological_process	protein monoubiquitination
A	0006974	biological_process	DNA damage response
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0019787	molecular_function	ubiquitin-like protein transferase activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032446	biological_process	protein modification by small protein conjugation
A	0035519	biological_process	protein K29-linked ubiquitination
A	0044314	biological_process	protein K27-linked ubiquitination
A	0051865	biological_process	protein autoubiquitination
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070534	biological_process	protein K63-linked ubiquitination
A	0070936	biological_process	protein K48-linked ubiquitination
A	0070979	biological_process	protein K11-linked ubiquitination
A	0085020	biological_process	protein K6-linked ubiquitination
B	0000166	molecular_function	nucleotide binding
B	0000209	biological_process	protein polyubiquitination
B	0003682	molecular_function	chromatin binding
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006281	biological_process	DNA repair
B	0006513	biological_process	protein monoubiquitination
B	0006974	biological_process	DNA damage response
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0019787	molecular_function	ubiquitin-like protein transferase activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032446	biological_process	protein modification by small protein conjugation
B	0035519	biological_process	protein K29-linked ubiquitination
B	0044314	biological_process	protein K27-linked ubiquitination
B	0051865	biological_process	protein autoubiquitination
B	0061631	molecular_function	ubiquitin conjugating enzyme activity
B	0070534	biological_process	protein K63-linked ubiquitination
B	0070936	biological_process	protein K48-linked ubiquitination
B	0070979	biological_process	protein K11-linked ubiquitination
B	0085020	biological_process	protein K6-linked ubiquitination
X	0004842	molecular_function	ubiquitin-protein transferase activity
X	0036297	biological_process	interstrand cross-link repair
X	0043240	cellular_component	Fanconi anaemia nuclear complex
Y	0004842	molecular_function	ubiquitin-protein transferase activity
Y	0036297	biological_process	interstrand cross-link repair
Y	0043240	cellular_component	Fanconi anaemia nuclear complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN X 1374

Chain	Residue
X	CYS307
X	CYS310
X	HIS334
X	CYS337

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN X 1375

Chain	Residue
X	CYS324
X	CYS329
X	CYS359
X	CYS362

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Y 1372

Chain	Residue
Y	CYS310
Y	HIS334
Y	CYS337
Y	CYS307

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Y 1373

Chain	Residue
Y	CYS324
Y	CYS329
Y	CYS359
Y	CYS362

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EPE A 1154

Chain	Residue
A	SER5
A	LYS8
A	ARG9
A	ARG9
X	ASP306
X	ASP306
X	TYR311
X	TYR313
X	TYR313
X	GLN314

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EPE A 1155

Chain	Residue
A	ARG35
A	LYS52

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 1153

Chain	Residue
B	ARG9
Y	TYR311

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL X 1376

Chain	Residue
A	ARG60
A	PHE63
A	GLU64
X	GLU340
X	TRP341
X	GLY344
X	LEU345

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1156

Chain	Residue
A	PRO19
A	GLY21
A	ILE22
A	THR23
A	GLN37
A	LEU39

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 1154

Chain	Residue
B	ILE68
B	ARG84
B	ILE85
B	NA1155

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1157

Chain	Residue
A	LEU140
A	ARG144
X	LYS369
Y	PHE303

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 1155

Chain	Residue
B	PRO66
B	LEU90
B	GOL1154

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 Y 1374

Chain	Residue
Y	ALA312
Y	TYR313
Y	GLN314

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NH4 X 1377

Chain	Residue
X	ASP321
X	GLN335

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNIdsa.GrICLdvL

Chain	Residue	Details
A	TYR75-LEU90

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	150
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"16916645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111657","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	56
Details	Zinc finger: {"description":"RING-type; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PDB","id":"4CCG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)