4C2Z

Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 1	polymer	410	47605.7	2	UniProt (P30419) Pfam (PF01233) Pfam (PF02799) In PDB	HOMO SAPIENS (HUMAN)	MYRISTOYL-COA\: PROTEIN N-MYRISTOYLTRANSFERASE 1, NMT 1, TYPE I N-MYRISTOYLTRANSFERASE, PEPTIDE N-MYRISTOYLTRANSFERASE 1,
2	A, B	TETRADECANOYL-COA	non-polymer		977.9	2	Chemie (MYA)
3	A, B	2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide	non-polymer		495.4	2	Chemie (646)
4	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	A, B	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT)
6	A, B	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
7	A, B	CHLORIDE ION	non-polymer		35.5	8	Chemie (CL)
8		water	water		18.0	537	Chemie (HOH)

Sequence modifications

A, B: 109 - 496 (UniProt: P30419)

PDB	External Database	Details
Met 87	-	expression tag
Gly 88	-	expression tag
Ser 89	-	expression tag
Ser 90	-	expression tag
His 91	-	expression tag
His 92	-	expression tag
His 93	-	expression tag
His 94	-	expression tag
His 95	-	expression tag
His 96	-	expression tag
Ser 97	-	expression tag
Ser 98	-	expression tag
Gly 99	-	expression tag
Leu 100	-	expression tag
Glu 101	-	expression tag
Val 102	-	expression tag
Leu 103	-	expression tag
Phe 104	-	expression tag
Gln 105	-	expression tag
Gly 106	-	expression tag
Pro 107	-	expression tag
His 108	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95211.4
Non-Polymers*	Number of molecules	20
	Total formula weight	4031.5
All*	Total formula weight	99242.9

*Water molecules are not included.