4C0D

Structure of the NOT module of the human CCR4-NOT complex (CNOT1-CNOT2-CNOT3)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1	polymer	812	92672.8	1	UniProt (A5YKK6) Pfam (PF04054)	HOMO SAPIENS (HUMAN)	CCR4-ASSOCIATED FACTOR 1, NEGATIVE REGULATOR OF TRANSCRIPTION SUBUNIT 1 HOMOLOG, NOT1H, HNOT1, CNOT1
2	B (B)	CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2	polymer	201	23313.5	1	UniProt (Q9NZN8) Pfam (PF04153)	HOMO SAPIENS (HUMAN)	CCR4-ASSOCIATED FACTOR 2, CNOT2
3	C (C)	CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3	polymer	166	20224.6	1	UniProt (O75175) Pfam (PF04153)	HOMO SAPIENS (HUMAN)	CCR4-ASSOCIATED FACTOR 3, LEUKOCYTE RECEPTOR CLUSTER MEMBER 2, CNOT3

Sequence modifications

A: 1565 - 2371 (UniProt: A5YKK6)

PDB	External Database	Details
Gly 1560	-	expression tag
His 1561	-	expression tag
Met 1562	-	expression tag
Leu 1563	-	expression tag
Glu 1564	-	expression tag

B: 344 - 540 (UniProt: Q9NZN8)

PDB	External Database	Details
Gly 340	-	expression tag
Pro 341	-	expression tag
His 342	-	expression tag
Met 343	-	expression tag

C: 607 - 753 (UniProt: O75175)

PDB	External Database	Details
Met 588	-	expression tag
Gly 589	-	expression tag
Ser 590	-	expression tag
Ser 591	-	expression tag
His 592	-	expression tag
His 593	-	expression tag
His 594	-	expression tag
His 595	-	expression tag
His 596	-	expression tag
His 597	-	expression tag
Ser 598	-	expression tag
Ser 599	-	expression tag
Gly 600	-	expression tag
Thr 601	-	expression tag
Gly 602	-	expression tag
Ser 603	-	expression tag
Gly 604	-	expression tag
His 605	-	expression tag
Met 606	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	136210.9
All*	Total formula weight	136210.9

*Water molecules are not included.