4BZS

Human angiotenisn converting enzyme N-domain in complex with K-26

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ANGIOTENSIN-CONVERTING ENZYME	polymer	629	72493.3	2	UniProt (P12821) Pfam (PF01401) In PDB	HOMO SAPIENS (HUMAN)	ACE, DIPEPTIDYL CARBOXYPEPTIDASE I, KININASE II, CD143, ANGIOTENSIN-CONVERTING ENZYME, SOLUBLE FORM
2	C, F	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	2	In PDB GlyTouCan (G86851RC)
3	D, G	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	E, H	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
7	A	2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL	non-polymer		354.4	1	Chemie (PE4)
8	A	HEXAETHYLENE GLYCOL	non-polymer		282.3	1	Chemie (P6G)
9	A, B	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	4	Chemie (PEG)
10	A, B	N-ACETYL-L-ILE-L-TYR-(R)-1-AMINO-2-(4-HYDROXYPHENYL)ETHYLPHOSPHONIC ACID	non-polymer		535.5	2	Chemie (K26)
11	A, B	thiodiglycolic acid	non-polymer		150.2	2	Chemie (9X6)
12	B	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
13		water	water		18.0	161	Chemie (HOH)

Sequence modifications

A, B: 1 - 628 (UniProt: P12821)

PDB	External Database	Details
Leu 629	-	expression tag
Leu 576	Pro 605	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	144986.5
Branched	Number of molecules	6
	Total formula weight	2756.6
Non-Polymers*	Number of molecules	15
	Total formula weight	2828.6
All*	Total formula weight	150571.7

*Water molecules are not included.