4BVY

Crystal structure of the AIMP3-MRS N-terminal domain complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	METHIONINE--TRNA LIGASE, CYTOPLASMIC	polymer	232	25884.3	1	UniProt (P56192) Pfam (PF18485) Pfam (PF00043) In PDB	HOMO SAPIENS (HUMAN)	METHIONYL-TRNA SYNTHETASE, METRS
2	B	EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1	polymer	186	21227.0	1	UniProt (O43324) Pfam (PF00043) In PDB	HOMO SAPIENS (HUMAN)	AIMP3 AMINOACYL TRNA SYNTHETASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 3, ELONGATION FACTOR P18, MULTISYNTHASE COMPLEX AUXILIARY COMPONENT P18
3		water	water		18.0	74	Chemie (HOH)

Sequence modifications

A: 1 - 225 (UniProt: P56192)

PDB	External Database	Details
Glu 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag
His 232	-	expression tag
Gln 36	Glu 36	conflict
Gln 187	Glu 187	conflict

B: 1 - 174 (UniProt: O43324)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Asp 37	Asn 37	conflict
Ser 147	Cys 147	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47111.3
All*	Total formula weight	47111.3

*Water molecules are not included.