4BVX

Crystal structure of the AIMP3-MRS N-terminal domain complex with I3C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	METHIONINE--TRNA LIGASE, CYTOPLASMIC	polymer	215	24060.4	1	UniProt (P56192) Pfam (PF18485) Pfam (PF00043)	HOMO SAPIENS (HUMAN)	METHIONYL-TRNA SYNTHETASE, METRS
2	B (B)	EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1	polymer	171	19479.3	1	UniProt (O43324) Pfam (PF21972)	HOMO SAPIENS (HUMAN)	AIMP3, AMINOACYL TRNA SYNTHETASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN ELONGATION FACTOR P18, MULTISYNTHASE COMPLEX AUXILIARY COMPONENT P18
3	C, D, E (A, B)	5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid	non-polymer		558.8	3	Chemie (I3C)
4	F, G (A, B)	water	water		18.0	178	Chemie (HOH)

Sequence modifications

A: 1 - 207 (UniProt: P56192)

PDB	External Database	Details
Leu 208	-	expression tag
Glu 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
Gln 36	Glu 36	conflict
Gln 187	Glu 187	conflict

B: 1 - 169 (UniProt: O43324)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag
Asp 37	Asn 37	conflict
Met 42	Thr 42	engineered mutation
Met 70	Ile 70	engineered mutation
Met 96	Lys 96	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43539.7
Non-Polymers*	Number of molecules	3
	Total formula weight	1676.5
All*	Total formula weight	45216.2

*Water molecules are not included.