4BV2
CRYSTAL STRUCTURE OF SIR2 IN COMPLEX WITH THE INHIBITOR EX-527, 2'-O-ACETYL-ADP-RIBOSE AND DEACETYLATED P53-PEPTIDE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-DEPENDENT PROTEIN DEACETYLASE | polymer | 246 | 27569.8 | 2 | UniProt (Q9WYW0) Pfam (PF02146) | THERMOTOGA MARITIMA | REGULATORY PROTEIN SIR2 HOMOLOG, SIR2TM, NAD-DEPENDENT PROTEIN DEACETYLASE SIR2 |
| 2 | C, D (E, H) | CELLULAR TUMOR ANTIGEN P53 | polymer | 13 | 1597.9 | 2 | UniProt (P04637) | HOMO SAPIENS | DEACETYLATED P53-PEPTIDE, ANTIGEN NY-CO-13, PHOSPHOPROTEIN P53, TUMOR SUPPRESSOR P53, P53 |
| 3 | E, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, H (A, B) | (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide | non-polymer | 248.7 | 2 | Chemie (OCZ) | |||
| 5 | G, I (A, B) | 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE | non-polymer | 601.4 | 2 | Chemie (OAD) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58335.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1830.9 | |
| All* | Total formula weight | 60166.3 |
