4BSW

Heterodimeric Fc Antibody Azymetric Variant 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HETERODIMERIC FC ANTIBODY AZYMETRIC VARIANT 2	polymer	226	25301.6	1	UniProt (P01857) Pfam (PF07654)	HOMO SAPIENS (HUMAN)
2	B (B)	HETERODIMERIC FC ANTIBODY AZYMETRIC VARIANT 2	polymer	226	25472.9	1	UniProt (P01857) Pfam (PF07654)	HOMO SAPIENS (HUMAN)
3	C, D (C, D)	beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1625.5	2	In PDB GlyTouCan (G27919IH)
4	E, G, I, J, K (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
5	F, H, L (A, B)	IODIDE ION	non-polymer		126.9	3	Chemie (IOD)
6	M, N (A, B)	water	water		18.0	371	Chemie (HOH)

Sequence modifications

A: 223 - 447 (UniProt: P01857)

PDB	External Database	Details
Gly 222	-	expression tag
Val 350	Thr 233	engineered mutation
Tyr 351	Leu 234	microheterogeneity
Leu 366	Thr 249	microheterogeneity
Leu 392	Lys 275	microheterogeneity
Thr 394	Trp 277	microheterogeneity
Ala 405	Phe 288	microheterogeneity
Val 407	Tyr 290	microheterogeneity

B: 223 - 447 (UniProt: P01857)

PDB	External Database	Details
Gly 222	-	expression tag
Val 350	Thr 233	engineered mutation
Tyr 351	Leu 234	microheterogeneity
Leu 366	Thr 249	microheterogeneity
Leu 392	Lys 275	microheterogeneity
Thr 394	Trp 277	microheterogeneity
Ala 405	Phe 288	microheterogeneity
Val 407	Tyr 290	microheterogeneity

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50774.5
Branched	Number of molecules	2
	Total formula weight	3251.0
Non-Polymers*	Number of molecules	8
	Total formula weight	691.1
All*	Total formula weight	54716.6

*Water molecules are not included.