4BSV
Heterodimeric Fc Antibody Azymetric Variant 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HETERODIMERIC FC ANTIBODY AZYMETRIC VARIANT 2 | polymer | 226 | 25301.6 | 1 | UniProt (P01857) Pfam (PF07654) | HOMO SAPIENS (HUMAN) | |
| 2 | B (B) | HETERODIMERIC FC ANTIBODY AZYMETRIC VARIANT 2 | polymer | 226 | 25490.9 | 1 | UniProt (P01857) Pfam (PF07654) | HOMO SAPIENS (HUMAN) | |
| 3 | C (C) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 4 | D (D) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G75031VE) | |||
| 5 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose | branched | 383.3 | 1 | In PDB GlyTouCan (G85856KC) | |||
| 6 | F (F) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G27919IH) | |||
| 7 | G, H, I, J, K... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 8 | P, Q, R (B) | IODIDE ION | non-polymer | 126.9 | 3 | Chemie (IOD) | |||
| 9 | S, T (A, B) | water | water | 18.0 | 753 | Chemie (HOH) |
Sequence modifications
A: 223 - 447 (UniProt: P01857)
B: 223 - 447 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Gly 222 | - | expression tag |
| Val 350 | Thr 233 | engineered mutation |
| Tyr 351 | Leu 234 | microheterogeneity |
| Leu 366 | Thr 249 | microheterogeneity |
| Met 392 | Lys 275 | microheterogeneity |
| Trp 394 | Thr 277 | microheterogeneity |
| Ala 405 | Phe 288 | microheterogeneity |
| Val 407 | Tyr 290 | microheterogeneity |
| PDB | External Database | Details |
|---|---|---|
| Gly 222 | - | expression tag |
| Val 350 | Thr 233 | engineered mutation |
| Tyr 351 | Leu 234 | microheterogeneity |
| Leu 366 | Thr 249 | microheterogeneity |
| Met 392 | Lys 275 | microheterogeneity |
| Thr 394 | Trp 277 | microheterogeneity |
| Ala 405 | Phe 288 | microheterogeneity |
| Val 407 | Tyr 290 | microheterogeneity |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50792.6 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3287.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 939.3 | |
| All* | Total formula weight | 55018.9 |
