4BSU
Structure of the ectodomain of LGR5 in complex with R-spondin-1 (Fu1Fu2) in C2 crystal form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, E, F (A, B, E, F) | LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5 | polymer | 539 | 60366.5 | 4 | UniProt (O75473) Pfam (PF01462) Pfam (PF13855) Pfam (PF12799) | HOMO SAPIENS (HUMAN) | G-PROTEIN COUPLED RECEPTOR 49, G-PROTEIN COUPLED RECEPTOR 67, G-PROTEIN COUPLED RECEPTOR HG38, LGR5 - LEUCINE-RICH REPEAT G-PROTEIN COUPLED RECEPTOR 5 |
| 2 | C, D, G, H (C, D, G, H) | R-SPONDIN-1 | polymer | 126 | 13706.8 | 4 | UniProt (Q2MKA7) Pfam (PF15913) | HOMO SAPIENS (HUMAN) | ROOF PLATE-SPECIFIC SPONDIN-1, HRSPO1 |
| 3 | I (I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | J, K, L (J, K, L) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 5 | M, N (B, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A, B, E, F: 22 - 543 (UniProt: O75473)
C, D, G, H: 31 - 146 (UniProt: Q2MKA7)
| PDB | External Database | Details |
|---|---|---|
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| Glu 14 | - | expression tag |
| Asn 15 | - | expression tag |
| Leu 16 | - | expression tag |
| Tyr 17 | - | expression tag |
| Phe 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Ala 544 | - | expression tag |
| Ala 545 | - | expression tag |
| Ala 546 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 29 | - | expression tag |
| Ser 30 | - | expression tag |
| Ala 147 | - | expression tag |
| Ala 148 | - | expression tag |
| His 149 | - | expression tag |
| His 150 | - | expression tag |
| His 151 | - | expression tag |
| His 152 | - | expression tag |
| His 153 | - | expression tag |
| His 154 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 296292.9 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2184.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 298919.4 |
