4BSK

Crystal structure of VEGF-C in complex with VEGFR-3 domains D1-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3	polymer	214	23856.6	1	UniProt (P35916) Pfam (PF22854) Pfam (PF21339)	HOMO SAPIENS (HUMAN)	VEGFR-3, FMS-LIKE TYROSINE KINASE 4, FLT-4, TYROSINE-PROTEIN KINASE RECEPTOR FLT4, VEGFR-3
2	B (C)	VASCULAR ENDOTHELIAL GROWTH FACTOR C	polymer	121	13594.5	1	UniProt (P49767) Pfam (PF00341)	HOMO SAPIENS (HUMAN)	VEGF-C, FLT4 LIGAND, FLT4-L, VASCULAR ENDOTHELIAL GROWTH FACTOR-RELATED PROTEIN, VRP, VEGF-C
3	C (B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	D, E, F, G (A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A: 23 - 229 (UniProt: P35916)

PDB	External Database	Details
Ala 230	-	cloning artifact
Asp 231	-	cloning artifact
Pro 232	-	cloning artifact
Ile 233	-	cloning artifact
Glu 234	-	cloning artifact
Gly 235	-	cloning artifact
Arg 236	-	cloning artifact

C: 103 - 215 (UniProt: P49767)

PDB	External Database	Details
Asp 101	-	expression tag
Pro 102	-	expression tag
Ala 137	Cys 137	engineered mutation
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	37451.1
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	38760.3

*Water molecules are not included.