4BQY
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Fe(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]alanine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | EGL NINE HOMOLOG 1 | polymer | 252 | 28096.9 | 1 | UniProt (Q9GZT9) Pfam (PF13640) In PDB | HOMO SAPIENS (HUMAN) | HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2, HIF-PH2, HIF-PROLYL HYDROXYLASE 2, HPH-2, PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2, PHD2, SM-20 |
| 2 | A | FE (II) ION | non-polymer | 55.8 | 1 | Chemie (FE2) | |||
| 3 | A | (2S)-2-{[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino}propanoic acid | non-polymer | 294.7 | 1 | Chemie (FNT) | |||
| 4 | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence modifications
A: 181 - 426 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Gly 175 | - | expression tag |
| Ser 176 | - | expression tag |
| His 177 | - | expression tag |
| Met 178 | - | expression tag |
| Ala 179 | - | expression tag |
| Ser 180 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28096.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 350.5 | |
| All* | Total formula weight | 28447.5 |
