4BQY

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Fe(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]alanine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0031418	molecular_function	L-ascorbic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 A 501

Chain	Residue
A	HIS313
A	ASP315
A	HIS374
A	FNT601
A	HOH2157

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE FNT A 601

Chain	Residue
A	HIS313
A	ASP315
A	ILE327
A	TYR329
A	HIS374
A	VAL376
A	ARG383
A	ARG398
A	FE2501
A	HOH2157
A	HOH2214
A	ASP254
A	MET299
A	TYR303
A	TYR310

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:16782814, ECO:0000269|PubMed:19604478, ECO:0000269|PubMed:28594552, ECO:0007744|PDB:2G19, ECO:0007744|PDB:3HQU, ECO:0007744|PDB:5V18

Chain	Residue	Details
A	HIS313
A	ASP315
A	HIS374

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:19604478

Chain	Residue	Details
A	ARG383

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site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:21601578

Chain	Residue	Details
A	CYS201
A	CYS208
A	CYS302
A	CYS323
A	CYS326

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