4BPU
Crystal structure of human primase in heterodimeric form, comprising PriS and truncated PriL lacking the C-terminal Fe-S domain.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | DNA PRIMASE SMALL SUBUNIT | polymer | 423 | 50108.0 | 2 | UniProt (P49642) Pfam (PF01896) In PDB | HOMO SAPIENS | DNA PRIMASE 49 KDA SUBUNIT, P49 |
2 | B, D | DNA PRIMASE LARGE SUBUNIT | polymer | 253 | 29782.2 | 2 | UniProt (P49643) In PDB | HOMO SAPIENS | DNA PRIMASE 58 KDA SUBUNIT, P58 |
3 | A, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
5 | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 420 (UniProt: P49642)
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Thr -1 | - | expression tag |
Ser 0 | - | expression tag |
Ala 72 | Lys 72 | engineered mutation |
Ala 73 | Met 73 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 159780.4 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 499.2 | |
All* | Total formula weight | 160279.6 |