4BPU
Crystal structure of human primase in heterodimeric form, comprising PriS and truncated PriL lacking the C-terminal Fe-S domain.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | DNA PRIMASE SMALL SUBUNIT | polymer | 423 | 50108.0 | 2 | UniProt (P49642) Pfam (PF01896) | HOMO SAPIENS | DNA PRIMASE 49 KDA SUBUNIT, P49 |
| 2 | B, D (B, D) | DNA PRIMASE LARGE SUBUNIT | polymer | 253 | 29782.2 | 2 | UniProt (P49643) | HOMO SAPIENS | DNA PRIMASE 58 KDA SUBUNIT, P58 |
| 3 | E, J (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, G, H, I (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 420 (UniProt: P49642)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 72 | Lys 72 | engineered mutation |
| Ala 73 | Met 73 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 159780.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 499.2 | |
| All* | Total formula weight | 160279.6 |
