4BN1
Crystal structure of V174M mutant of Aurora-A kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | AURORA KINASE A | polymer | 285 | 33140.8 | 1 | UniProt (O14965) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | AURORA 2, AURORA/IPL1-RELATED KINASE 1, ARK-1, AURORA-RELAT ED KINASE 1, HARK1, BREAST TUMOR-AMPLIFIED KINASE, SERINE/THREONIN E-PROTEIN KINASE 15, SERINE/THREONINE-PROTEIN KINASE 6, SERINE/THR EONINE-PROTEIN KINASE AURORA-A, AURORA-A |
| 2 | B (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 3 | C, D (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | E (A) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | expression tag |
| Ala 120 | - | expression tag |
| Met 121 | - | expression tag |
| Met 174 | Val 174 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33140.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 507.4 | |
| All* | Total formula weight | 33648.2 |
