4BKP

Crystal structure of human GDP-L-fucose synthase with bound NADP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	GDP-L-FUCOSE SYNTHASE	polymer	336	37807.6	4	UniProt (Q13630) Pfam (PF01370)	HOMO SAPIENS (HUMAN)	GDP-4-KETO-6-DEOXY-D-MANNOSE-3,5-EPIMERASE-4-REDUCTASE, PROTEIN FX, RED CELL NADP(H)-BINDING PROTEIN, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 4E MEMBER 1
2	E, G, H, I (A, B, C, D)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	4	Chemie (NAP)
3	F (A)	CITRATE ANION	non-polymer		189.1	1	Chemie (FLC)
4	J (D)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	K, L, M, N (A, B, C, D)	water	water		18.0	50	Chemie (HOH)

Sequence modifications

A, B, C, D: 8 - 321 (UniProt: Q13630)

PDB	External Database	Details
Met -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
Ser -15	-	expression tag
Ser -14	-	expression tag
Gly -13	-	expression tag
Val -12	-	expression tag
Asp -11	-	expression tag
Leu -10	-	expression tag
Gly -9	-	expression tag
Thr -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Ser -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	151230.3
Non-Polymers*	Number of molecules	6
	Total formula weight	3224.8
All*	Total formula weight	154455.1

*Water molecules are not included.