4BKJ
Crystal structure of the human DDR1 kinase domain in complex with imatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 | polymer | 315 | 35754.1 | 2 | UniProt (Q08345) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | EPITHELIAL DISCOIDIN DOMAIN RECEPTOR 1, CD167 ANTIGEN-LIKE FAMILY MEMBER A, CELL ADHESION KINASE, DISCOIDIN RECEPTOR TYROSINE KINASE, HGK2, MAMMARY CARCINOMA KINASE 10, MCK-10, PROTEIN-TYROSINE KINASE 3A, PROTEIN-TYROSINE KINASE RTK-6, TRK E, TYROSINE KINASE DDR, TYROSINE-PROTEIN KINASE CAK, CD167A |
| 2 | A, B | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | non-polymer | 493.6 | 2 | Chemie (STI) | |||
| 3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 19 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
A, B: 601 - 913 (UniProt: Q08345)
| PDB | External Database | Details |
|---|---|---|
| Ser 599 | - | expression tag |
| Met 600 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71508.2 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 2166.5 | |
| All* | Total formula weight | 73674.7 |
