Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE STI A 1000 |
| Chain | Residue |
| A | VAL624 |
| A | VAL763 |
| A | HIS764 |
| A | LEU773 |
| A | ALA783 |
| A | ASP784 |
| A | PHE785 |
| A | HOH2208 |
| A | ALA653 |
| A | LYS655 |
| A | GLU672 |
| A | MET676 |
| A | ILE685 |
| A | THR701 |
| A | TYR703 |
| A | MET704 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1001 |
| Chain | Residue |
| A | ASN706 |
| A | PHE712 |
| A | GLY775 |
| A | GLU776 |
| A | ASN777 |
| A | PHE778 |
| A | HOH2083 |
| A | HOH2120 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO A 1002 |
| Chain | Residue |
| A | MET810 |
| A | ALA811 |
| A | TRP812 |
| A | ILE815 |
| A | TRP827 |
| A | PHE845 |
| A | VAL853 |
| A | ASN856 |
| A | ALA857 |
| A | EDO1007 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1003 |
| Chain | Residue |
| A | TRP812 |
| A | GLU813 |
| A | ARG890 |
| A | SER892 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1004 |
| Chain | Residue |
| A | THR822 |
| A | PRO897 |
| A | PHE898 |
| A | SER899 |
| A | EDO1006 |
| A | HOH2197 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1005 |
| Chain | Residue |
| A | ASN683 |
| A | ALA748 |
| A | GLN749 |
| A | SER752 |
| A | HIS902 |
| A | HOH2071 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1006 |
| Chain | Residue |
| A | THR822 |
| A | ALA823 |
| A | SER892 |
| A | ARG895 |
| A | PRO897 |
| A | VAL913 |
| A | EDO1004 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1007 |
| Chain | Residue |
| A | TRP827 |
| A | PHE845 |
| A | TYR869 |
| A | LEU870 |
| A | TRP888 |
| A | EDO1002 |
| A | HOH2133 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1008 |
| Chain | Residue |
| A | ASP634 |
| A | VAL636 |
| A | PHE712 |
| A | HIS716 |
| A | PRO736 |
| A | THR737 |
| A | HOH2026 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1009 |
| Chain | Residue |
| A | HIS745 |
| A | GLN749 |
| A | ASN777 |
| A | THR779 |
| A | HOH2071 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1010 |
| Chain | Residue |
| A | HOH2211 |
| B | ASP668 |
| B | GLU672 |
| site_id | BC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE STI B 1000 |
| Chain | Residue |
| B | VAL624 |
| B | ALA653 |
| B | LYS655 |
| B | GLU672 |
| B | MET676 |
| B | ILE685 |
| B | MET699 |
| B | THR701 |
| B | TYR703 |
| B | MET704 |
| B | VAL763 |
| B | HIS764 |
| B | LEU773 |
| B | ALA783 |
| B | ASP784 |
| B | PHE785 |
| B | HOH2160 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1001 |
| Chain | Residue |
| B | VAL913 |
| B | EDO1002 |
| B | HOH2158 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1002 |
| Chain | Residue |
| B | CYS876 |
| B | PRO877 |
| B | EDO1001 |
| B | HOH2128 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1003 |
| Chain | Residue |
| B | ARG895 |
| B | PRO897 |
| B | VAL913 |
| B | EDO1004 |
| B | HOH2159 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1004 |
| Chain | Residue |
| B | THR822 |
| B | PRO897 |
| B | PHE898 |
| B | SER899 |
| B | EDO1003 |
| B | HOH2149 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1005 |
| Chain | Residue |
| B | GLU813 |
| B | ARG890 |
| B | GLU891 |
| B | SER892 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1006 |
| Chain | Residue |
| B | ASN706 |
| B | GLY775 |
| B | GLU776 |
| B | ASN777 |
| B | PHE778 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 1007 |
| Chain | Residue |
| B | ILE807 |
| B | ARG808 |
| B | MET810 |
| B | ILE815 |
| B | PHE845 |
| B | VAL853 |
| B | ASN856 |
| B | HOH2086 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1008 |
| Chain | Residue |
| B | GLY818 |
| B | LYS819 |
| B | PHE820 |
| B | ASN911 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 1009 |
| Chain | Residue |
| A | ARG607 |
| A | LEU610 |
| A | ILE656 |
| A | HOH2008 |
| A | HOH2021 |
| B | GLN847 |
| B | THR849 |
| B | GLN852 |
Functional Information from PROSITE/UniProt
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV |
| Chain | Residue | Details |
| A | PHE762-VAL774 | |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. NLYagdYYR |
| Chain | Residue | Details |
| A | ASN790-ARG798 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16337946","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"24509848","evidenceCode":"ECO:0000269"}]} |
