4BF2
Crystal Structures of Ask1-inhibitor Complexes
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5 | polymer | 334 | 37518.5 | 2 | UniProt (Q99683) Pfam (PF00069) In PDB | HOMO SAPIENS | APOPTOSIS SIGNAL-REGULATING KINASE 1, ASK-1, MAPK/ERK KINASE KINASE 5, MEK KINASE 5, MEKK 5, ASK1 |
2 | A, B | STAUROSPORINE | non-polymer | 466.5 | 2 | Chemie (STU) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | B | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
5 | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B: 660 - 977 (UniProt: Q99683)
PDB | External Database | Details |
---|---|---|
Met 644 | - | expression tag |
Asp 645 | - | expression tag |
Tyr 646 | - | expression tag |
Lys 647 | - | expression tag |
Asp 648 | - | expression tag |
Asp 649 | - | expression tag |
Asp 650 | - | expression tag |
Asp 651 | - | expression tag |
Lys 652 | - | expression tag |
Glu 653 | - | expression tag |
Asn 654 | - | expression tag |
Leu 655 | - | expression tag |
Tyr 656 | - | expression tag |
Phe 657 | - | expression tag |
Gln 658 | - | expression tag |
Gly 659 | - | expression tag |
Glu 838 | Thr 838 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 75036.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1084.2 | |
All* | Total formula weight | 76121.1 |