4B9K
pVHL-ELOB-ELOC complex_(2S,4R)-1-(3-amino-2-methylbenzoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J | TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 | polymer | 104 | 11956.4 | 4 | UniProt (Q15370) Pfam (PF00240) In PDB | HOMO SAPIENS (HUMAN) | ELONGIN 18 KDA SUBUNIT, ELONGIN-B, ELOB, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT B, SIII P18 |
| 2 | B, H, K | TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1 | polymer | 97 | 10974.6 | 3 | UniProt (Q15369) Pfam (PF03931) In PDB | HOMO SAPIENS (HUMAN) | ELONGIN 15 KDA SUBUNIT, ELONGIN-C, ELOC, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT C, SIII P15 |
| 3 | C, F, I, L | VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR | polymer | 171 | 19906.5 | 4 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB | HOMO SAPIENS (HUMAN) | PROTEIN G7, PVHL |
| 4 | E | TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1 | polymer | 97 | 11078.6 | 1 | UniProt (Q15369) Pfam (PF03931) In PDB | HOMO SAPIENS (HUMAN) | ELONGIN 15 KDA SUBUNIT, ELONGIN-C, ELOC, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT C, SIII P15 |
| 5 | C, F, I, L | (2S,4R)-1-(3-amino-2-methylbenzoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | non-polymer | 450.6 | 4 | Chemie (TG0) | |||
| 6 | F, H, I, K, L | ACETATE ION | non-polymer | 59.0 | 8 | Chemie (ACT) | |||
| 7 | water | water | 18.0 | 893 | Chemie (HOH) |
Sequence modifications
B, H, K: 17 - 112 (UniProt: Q15369)
C, F, I, L: 54 - 213 (UniProt: P40337)
E: 17 - 112 (UniProt: Q15369)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 43 | - | expression tag |
| Met 44 | - | expression tag |
| Ser 45 | - | expression tag |
| Glu 46 | - | expression tag |
| Asn 47 | - | expression tag |
| Leu 48 | - | expression tag |
| Tyr 49 | - | expression tag |
| Phe 50 | - | expression tag |
| Gln 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 171453.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2274.6 | |
| All* | Total formula weight | 173728.4 |
