4B9K

pVHL-ELOB-ELOC complex_(2S,4R)-1-(3-amino-2-methylbenzoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0030891	cellular_component	VCB complex
A	0070449	cellular_component	elongin complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0030891	cellular_component	VCB complex
D	0070449	cellular_component	elongin complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0030891	cellular_component	VCB complex
G	0070449	cellular_component	elongin complex
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0030891	cellular_component	VCB complex
J	0070449	cellular_component	elongin complex
K	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT I 1209

Chain	Residue
I	ARG161
I	HOH2076

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT F 1205

Chain	Residue
F	ARG161
F	SER168
F	HOH2081

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT K 1113

Chain	Residue
K	TYR18
K	ASN58

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT H 1113

Chain	Residue
H	ARG63
H	GLU64
F	GLY106
H	PHE62

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT L 1208

Chain	Residue
L	GLN96
L	PRO97

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TG0 I 1210

Chain	Residue
I	PHE76
I	TRP88
I	TYR98
I	PRO99
I	ARG107
I	ILE109
I	HIS110
I	SER111
I	HIS115
I	TRP117
I	HOH2024

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TG0 L 1209

Chain	Residue
L	TRP88
L	PHE91
L	TYR98
L	PRO99
L	ARG107
L	ILE109
L	HIS110
L	SER111
L	TYR112
L	HIS115
L	TRP117
L	HOH2037
L	HOH2099
L	HOH2100

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TG0 F 1206

Chain	Residue
F	TRP88
F	PHE91
F	TYR98
F	PRO99
F	ARG107
F	ILE109
F	HIS110
F	SER111
F	TYR112
F	HIS115
F	TRP117
F	HOH2042
I	ARG182

---

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TG0 C 1203

Chain	Residue
C	TRP88
C	PHE91
C	TYR98
C	PRO99
C	ARG107
C	ILE109
C	HIS110
C	SER111
C	TYR112
C	HIS115
C	TRP117
C	HOH2084
L	ARG182

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT L 1210

Chain	Residue
L	ASN90
L	PHE91
L	ASP92
L	HOH2040
L	HOH2099

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT H 1114

Chain	Residue
F	ARG108
F	HOH2038
H	SER39
H	GLY40
H	THR41
H	LEU110
H	ASP111
H	CYS112

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT F 1207

Chain	Residue
F	ARG167
F	SER168
F	VAL170
F	HOH2071

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Region: {"description":"Interaction with Elongin BC complex"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	165
Details	Region: {"description":"Involved in binding to CCT complex"}

Chain

Residue

Details

---