4B8Z

Crystal structure of human GDP-L-fucose synthase with bound NADP and GDP, rhombohedral crystal form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	GDP-L-FUCOSE SYNTHASE	polymer	320	36001.6	4	UniProt (Q13630) Pfam (PF01370) In PDB	HOMO SAPIENS (HUMAN)	GDP-4-KETO-6-DEOXY-D-MANNOSE-3,5-EPIMERASE-4-REDUCTASE, PROTEIN FX, RED CELL NADP(H)-BINDING PROTEIN, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 4E MEMBER 1
2	A, B, C, D	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	4	Chemie (NAP)
3	A, B, C, D	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	4	Chemie (GDP)
4		water	water		18.0	18	Chemie (HOH)

Sequence modifications

A, B, C, D: 8 - 320 (UniProt: Q13630)

PDB	External Database	Details
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Ser -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	144006.4
Non-Polymers*	Number of molecules	8
	Total formula weight	4746.4
All*	Total formula weight	148752.8

*Water molecules are not included.