4AYD

Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 R106A mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E (A, B, E)	COMPLEMENT FACTOR H	polymer	125	14410.3	3	UniProt (P08603) Pfam (PF00084)	HOMO SAPIENS (HUMAN)	H FACTOR 1
2	C, D, F (C, D, F)	FACTOR H BINDING PROTEIN	polymer	257	27613.8	3	UniProt (Q9JXV4) Pfam (PF20937) Pfam (PF08794)	NEISSERIA MENINGITIDIS
3	G, H, I, J (C, D, E, F)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
4	K, L, M, N, O... (A, B, C, D, E...)	water	water		18.0	826	Chemie (HOH)

Sequence modifications

A, B, E: 321 - 443 (UniProt: P08603)

PDB	External Database	Details
Met 319	-	expression tag
Gly 320	-	expression tag
His 402	Tyr 402	variant

C, D, F: 73 - 320 (UniProt: Q9JXV4)

PDB	External Database	Details
Met 72	-	expression tag
Glu 321	-	expression tag
Leu 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
Ala 106	Arg 106	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	126072.3
Non-Polymers*	Number of molecules	4
	Total formula weight	248.3
All*	Total formula weight	126320.6

*Water molecules are not included.