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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4AQV

Model of human kinesin-5 motor domain (3HQD) and mammalian tubulin heterodimer (1JFF) docked into the 9.7-angstrom cryo-EM map of microtubule-bound kinesin-5 motor domain in the AMPPPNP state.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		TUBULIN ALPHA-1D CHAINpolymer45250236.41UniProt (Q2HJ86)
Pfam (PF00091)
Pfam (PF03953)		BOS TAURUS (CATTLE)ALPHA-TUBULIN
2B
(B)		TUBULIN BETA-2B CHAINpolymer44549907.81UniProt (Q6B856)
Pfam (PF00091)
Pfam (PF03953)		BOS TAURUS (CATTLE)BETA-TUBULIN
3C
(C)		KINESIN-LIKE PROTEIN KIF11polymer37341673.11UniProt (P52732)
Pfam (PF00225)		HOMO SAPIENS (HUMAN)KINESIN-5, KINESIN-LIKE PROTEIN 1, KINESIN-LIKE SPINDLE PRO KINESIN-RELATED MOTOR PROTEIN EG5, THYROID RECEPTOR-INTERACTING PROTEIN 5, TR-INTERACTING PROTEIN 5, TRIP-5
4D, I
(A, C)		MAGNESIUM IONnon-polymer24.32Chemie (MG)
PubChem (888)
5E
(A)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
PubChem (135600366)
PubChem (135749822)
PubChem (136664747)
PubChem (136803486)
PubChem (164715984)
PubChem (135398633)
PubChem (135400627)
PubChem (135487750)
PubChem (135544356)
PubChem (135547949)
PubChem (136005188)
PubChem (136073923)
PubChem (136088935)
PubChem (136240914)
PubChem (136772743)
PubChem (136772744)
PubChem (136803487)
PubChem (137286749)
PubChem (171699466)
6F
(B)		GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
PubChem (172898537)
PubChem (135398619)
PubChem (135402030)
PubChem (135431654)
PubChem (135566337)
PubChem (135760556)
PubChem (136026707)
PubChem (136053418)
PubChem (136073927)
PubChem (136663964)
PubChem (136664748)
PubChem (136759848)
PubChem (136759849)
PubChem (136759850)
PubChem (136836636)
PubChem (136847074)
7G
(B)		TAXOLnon-polymer853.91Chemie (TA1)
PubChem (101598423)
PubChem (124747273)
PubChem (126761000)
PubChem (129395998)
PubChem (46782671)
PubChem (4666)
PubChem (160585532)
PubChem (36314)
PubChem (60915)
PubChem (163077211)
PubChem (167423928)
PubChem (177409)
PubChem (184492)
PubChem (441276)
PubChem (118528174)
PubChem (121459571)
PubChem (5317123)
PubChem (5321715)
PubChem (5352019)
PubChem (122361554)
PubChem (124747271)
PubChem (124747272)
PubChem (124747274)
PubChem (124893098)
PubChem (6604028)
PubChem (6604616)
PubChem (6604814)
PubChem (6713921)
PubChem (6915727)
PubChem (126968948)
PubChem (129627423)
PubChem (9875988)
PubChem (132517454)
PubChem (133052515)
PubChem (133640187)
PubChem (134368714)
PubChem (134715514)
PubChem (134972678)
PubChem (10033513)
PubChem (10485732)
PubChem (10748131)
PubChem (11320430)
PubChem (11354895)
PubChem (11506104)
PubChem (11828953)
PubChem (14060298)
PubChem (14060299)
PubChem (14060304)
PubChem (14060306)
PubChem (137705323)
PubChem (138106885)
PubChem (15983941)
PubChem (16742549)
PubChem (16757828)
PubChem (16760177)
PubChem (16760674)
PubChem (21733096)
PubChem (140512017)
PubChem (140731501)
PubChem (143890766)
PubChem (144453087)
PubChem (146034004)
PubChem (23307219)
PubChem (23307242)
PubChem (23307253)
PubChem (23307913)
PubChem (23412627)
PubChem (23636632)
PubChem (24207713)
PubChem (24754091)
PubChem (24791027)
PubChem (152743329)
PubChem (153289350)
PubChem (154037993)
PubChem (154828192)
PubChem (155982214)
PubChem (24848897)
PubChem (24867246)
PubChem (25200067)
PubChem (159121804)
PubChem (159716711)
PubChem (160053861)
PubChem (160171678)
PubChem (160585530)
PubChem (42613129)
PubChem (42620039)
PubChem (44155032)
PubChem (44276363)
PubChem (44279927)
PubChem (44291178)
PubChem (44328863)
PubChem (44335735)
PubChem (44342632)
PubChem (44356895)
PubChem (44378736)
PubChem (44403716)
PubChem (45489039)
PubChem (46781469)
PubChem (57489669)
PubChem (57908851)
PubChem (57946364)
PubChem (57999380)
PubChem (58460861)
PubChem (58596717)
PubChem (58777027)
PubChem (58798493)
PubChem (58803237)
PubChem (58877402)
PubChem (49868078)
PubChem (163077209)
PubChem (163077210)
PubChem (163077212)
PubChem (163077213)
PubChem (163077214)
PubChem (163077215)
PubChem (163284947)
PubChem (53298534)
PubChem (53313247)
PubChem (165084161)
PubChem (54259297)
PubChem (54259298)
PubChem (54259299)
PubChem (166711459)
PubChem (168322423)
PubChem (169917882)
PubChem (170014955)
PubChem (59042813)
PubChem (59048611)
PubChem (170362150)
PubChem (171036874)
PubChem (5460441)
PubChem (59844545)
PubChem (59873251)
PubChem (59904698)
PubChem (59919147)
PubChem (60005248)
PubChem (60011010)
PubChem (60123436)
PubChem (60123443)
PubChem (60147315)
PubChem (66795656)
PubChem (175758871)
PubChem (70801836)
PubChem (70842048)
PubChem (70848451)
PubChem (70856170)
PubChem (70943371)
PubChem (71096818)
PubChem (71209844)
PubChem (9854162)
PubChem (9897470)
PubChem (73707502)
PubChem (73759704)
PubChem (73759783)
PubChem (89493063)
PubChem (89847578)
PubChem (90057663)
PubChem (91122402)
PubChem (14060309)
PubChem (91885464)
PubChem (21458255)
PubChem (101920282)
PubChem (44323108)
PubChem (44356961)
PubChem (59914794)
PubChem (176586897)
8H
(C)		PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.21Chemie (ANP)
PubChem (4795)
PubChem (33113)
PubChem (445863)
PubChem (6102784)
PubChem (9543492)
PubChem (14188278)
PubChem (16058657)
PubChem (23639785)
PubChem (24794410)
PubChem (44462678)
PubChem (46926537)
PubChem (54765332)
PubChem (60063697)
PubChem (66575078)
PubChem (89688694)
PubChem (92436779)
PubChem (93005803)
Sequence modifications
A: 1 - 452 (UniProt: Q2HJ86)
PDBExternal DatabaseDetails
Ile 7Val 7conflict
Ile 114Leu 114conflict
Ser 136Leu 136conflict
Val 137Ile 137conflict
Gly 265Ile 265conflict
Glu 358Gln 358conflict
Val 437Met 437conflict
Glu 450Asp 450conflict
B: 1 - 455 (UniProt: Q6B856)
PDBExternal DatabaseDetails
Ala 57Thr 55conflict
Val 172Met 170conflict
Ala 298Ser 296conflict
Val 318Ile 316conflict
C: 1 - 367 (UniProt: P52732)
PDBExternal DatabaseDetails
Val 25Cys 25engineered mutation
Ser 43Cys 43engineered mutation
Ala 87Cys 87engineered mutation
Ala 99Cys 99engineered mutation
Cys 126Thr 126engineered mutation
His 368-expression tag
His 369-expression tag
His 370-expression tag
His 371-expression tag
His 372-expression tag
His 373-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight141817.2
Non-Polymers*Number of molecules6
Total formula weight2375.1
All*Total formula weight144192.3
*Water molecules are not included.

251174

PDB entries from 2026-03-25

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