4APC

Crystal Structure of Human NIMA-related Kinase 1 (NEK1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	SERINE/THREONINE-PROTEIN KINASE NEK1	polymer	350	39912.1	2	UniProt (Q96PY6) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	NEVER IN MITOSIS A-RELATED KINASE 1, NIMA-RELATED PROTEIN KINASE 1, RENAL CARCINOMA ANTIGEN NY-REN-55
2	C, D, E, F, G... (A, B)	CHLORIDE ION	non-polymer		35.5	7	Chemie (CL)
3	J, K (A, B)	water	water		18.0	165	Chemie (HOH)

Sequence modifications

A, B: 1 - 328 (UniProt: Q96PY6)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag
Ala 162	Thr 162	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	79824.1
Non-Polymers*	Number of molecules	7
	Total formula weight	248.2
All*	Total formula weight	80072.3

*Water molecules are not included.