4AOJ
Human TrkA in complex with the inhibitor AZ-23
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR | polymer | 329 | 36898.4 | 3 | UniProt (P04629) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1, TRK1-TRANSFORMING TYROSINE KINASE PROTEIN, TROPOMYOSIN-RELATED KINASE A, TYROSINE KINASE RECEPTOR, TYROSINE KINASE RECEPTOR A, TRK-A, GP140TRK, P140-TRKA, TRKA |
| 2 | D, G, J (A, B, C) | 5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine | non-polymer | 391.8 | 3 | Chemie (V4Z) | |||
| 3 | E, F, H, I, K... (A, B, C) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | M, N, O (A, B, C) | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
A, B, C: 473 - 796 (UniProt: P04629)
| PDB | External Database | Details |
|---|---|---|
| Gly 468 | - | expression tag |
| Ala 469 | - | expression tag |
| Met 470 | - | expression tag |
| Gly 471 | - | expression tag |
| Ser 472 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 110695.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1567.9 | |
| All* | Total formula weight | 112263.1 |
