4AOJ
Human TrkA in complex with the inhibitor AZ-23
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004713 | molecular_function | protein tyrosine kinase activity |
| C | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE V4Z A 900 |
| Chain | Residue |
| A | LEU516 |
| A | ASP596 |
| A | ARG654 |
| A | ASN655 |
| A | CYS656 |
| A | LEU657 |
| A | GLY667 |
| A | ASP668 |
| A | HOH2036 |
| A | VAL524 |
| A | ALA542 |
| A | PHE589 |
| A | GLU590 |
| A | TYR591 |
| A | MET592 |
| A | ARG593 |
| A | GLY595 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE V4Z B 900 |
| Chain | Residue |
| B | LEU516 |
| B | VAL524 |
| B | ALA542 |
| B | PHE589 |
| B | GLU590 |
| B | TYR591 |
| B | MET592 |
| B | ARG593 |
| B | GLY595 |
| B | ARG654 |
| B | ASN655 |
| B | LEU657 |
| B | GLY667 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE V4Z C 900 |
| Chain | Residue |
| C | LEU516 |
| C | VAL524 |
| C | ALA542 |
| C | GLU590 |
| C | TYR591 |
| C | MET592 |
| C | GLY595 |
| C | ASP596 |
| C | ARG654 |
| C | ASN655 |
| C | CYS656 |
| C | LEU657 |
| C | GLY667 |
| C | ASP668 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1790 |
| Chain | Residue |
| A | HIS504 |
| A | CYS579 |
| A | GLU581 |
| C | CYS501 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1791 |
| Chain | Residue |
| A | GLU515 |
| A | GLU518 |
| A | LYS523 |
| C | HIS645 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1792 |
| Chain | Residue |
| A | CYS501 |
| B | HIS504 |
| B | CYS579 |
| B | GLU581 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1793 |
| Chain | Residue |
| A | HIS645 |
| B | GLU515 |
| B | GLU518 |
| B | LYS523 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1790 |
| Chain | Residue |
| B | CYS501 |
| C | HIS504 |
| C | CYS579 |
| C | GLU581 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1791 |
| Chain | Residue |
| B | HIS645 |
| C | GLU515 |
| C | GLU518 |
| C | LYS523 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVFlAechnllpeqdkml.....VAVK |
| Chain | Residue | Details |
| A | LEU516-LYS544 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV |
| Chain | Residue | Details |
| A | PHE646-VAL658 |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYstdYYR |
| Chain | Residue | Details |
| A | ASP674-ARG682 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interaction with PLCG1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"15488758","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7510697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8155326","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Motif: {"description":"DXXLL","evidences":[{"source":"PubMed","id":"26446845","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
