4AMI
Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | BETA-1 ADRENERGIC RECEPTOR | polymer | 315 | 35940.8 | 2 | UniProt (P07700) Pfam (PF00001) In PDB | MELEAGRIS GALLOPAVO (TURKEY) | BETA-1 ADRENORECEPTOR, BETA-1 ADRENOCEPTOR, BETA-T |
2 | A, B | 2-[(2S)-3-[[1-(1H-indol-3-yl)-2-methyl-propan-2-yl]amino]-2-oxidanyl-propoxy]benzenecarbonitrile | non-polymer | 363.5 | 2 | Chemie (G90) | |||
3 | A, B | HEGA-10 | non-polymer | 379.5 | 5 | Chemie (2CV) | |||
4 | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A, B: 33 - 243 (UniProt: P07700)
A, B: 272 - 368 (UniProt: P07700)
PDB | External Database | Details |
---|---|---|
Met 31 | - | expression tag |
Gly 32 | - | expression tag |
His 369 | - | expression tag |
His 370 | - | expression tag |
His 371 | - | expression tag |
His 372 | - | expression tag |
His 373 | - | expression tag |
Ser 68 | Arg 68 | engineered mutation |
Val 90 | Met 90 | engineered mutation |
Leu 116 | Cys 116 | engineered mutation |
Ala 227 | Tyr 227 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Leu 282 | Ala 282 | engineered mutation |
Ala 327 | Phe 327 | engineered mutation |
Met 338 | Phe 338 | engineered mutation |
Ala 358 | Cys 358 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 71881.6 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2624.4 | |
All* | Total formula weight | 74505.9 |