4AK8

Structure of F241L mutant of langerin carbohydrate recognition domain.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER K	polymer	155	17888.1	4	UniProt (Q9UJ71) Pfam (PF00059)	HOMO SAPIENS (HUMAN)	LANGERIN, CD_ANTIGEN=CD207
2	E, G, I, L (A, B, C, D)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
3	F, H, J, M (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	K (D)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	N, O, P, Q (A, B, C, D)	water	water		18.0	807	Chemie (HOH)

Sequence modifications

A, B, C, D: 188 - 328 (UniProt: Q9UJ71)

PDB	External Database	Details
Met 174	-	expression tag
Trp 175	-	expression tag
Ser 176	-	expression tag
His 177	-	expression tag
Pro 178	-	expression tag
Gln 179	-	expression tag
Phe 180	-	expression tag
Glu 181	-	expression tag
Lys 182	-	expression tag
Ile 183	-	expression tag
Glu 184	-	expression tag
Gly 185	-	expression tag
Arg 186	-	expression tag
Met 187	-	expression tag
Leu 241	Phe 241	engineered mutation
Ala 278	Val 278	variant

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	71552.2
Non-Polymers*	Number of molecules	9
	Total formula weight	293.0
All*	Total formula weight	71845.2

*Water molecules are not included.