4AG4

Crystal structure of a DDR1-Fab complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1	polymer	351	39354.3	1	UniProt (Q08345) Pfam (PF00754) Pfam (PF21114)	HOMO SAPIENS (HUMAN)	EPITHELIAL DISCOIDIN DOMAIN RECEPTOR 1, CD167 ANTIGEN-LIKE FAMILY MEMBER A, CELL ADHESION KINASE, DISCOIDIN RECEPTOR TYROSINE KINASE, HGK2, MAMMARY CARCINOMA KINASE 10, MCK-10, PROTEIN-TYROSINE KINASE 3A, PROTEIN-TYROSINE KINASE RTK-6, TRK E, TYROSINE KINASE DDR, TYROSINE-PROTEIN KINASE CAK, CD167A
2	B (H)	MONOCLONAL ANTIBODY 3E3 HEAVY CHAIN	polymer	215	23025.7	1		MUS MUSCULUS (HOUSE MOUSE)
3	C (L)	MONOCLONAL ANTIBODY 3E3 LIGHT CHAIN	polymer	213	23410.8	1		MUS MUSCULUS (HOUSE MOUSE)
4	D, E (B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	F, G (A)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
6	H, I, J (A, H, L)	water	water		18.0	14	Chemie (HOH)

Sequence modifications

A: 29 - 367 (UniProt: Q08345)

PDB	External Database	Details
Ala 26	-	expression tag
Pro 27	-	expression tag
Leu 28	-	expression tag
Ala 368	-	expression tag
Ala 369	-	expression tag
Ala 370	-	expression tag
His 371	-	expression tag
His 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	85790.8
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	86719.7

*Water molecules are not included.