4AF0

Crystal structure of cryptococcal inosine monophosphate dehydrogenase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE	polymer	556	59377.4	1	UniProt (E3P6S0)	CRYPTOCOCCUS NEOFORMANS
2	B (B)	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE	polymer	556	59363.3	1	UniProt (E3P6S0)	CRYPTOCOCCUS NEOFORMANS
3	C, E (A, B)	MYCOPHENOLIC ACID	non-polymer		320.3	2	Chemie (MOA)
4	D, F (A, B)	INOSINIC ACID	non-polymer		348.2	2	Chemie (IMP)
5	G, H (B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	I, J (A, B)	water	water		18.0	515	Chemie (HOH)

Sequence modifications

A: 1 - 544 (UniProt: E3P6S0)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 501	Gly 501	conflict

B: 1 - 544 (UniProt: E3P6S0)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	118740.7
Non-Polymers*	Number of molecules	6
	Total formula weight	1529.2
All*	Total formula weight	120269.9

*Water molecules are not included.