4A9E

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3-methyl-1,2,3,4- tetrahydroquinazolin-2-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	BROMODOMAIN-CONTAINING PROTEIN 2	polymer	154	17908.7	3	UniProt (P25440) Pfam (PF00439)	HOMO SAPIENS (HUMAN)	HUMAN BRD2
2	D, I, L (A, B, C)	3-methyl-3,4-dihydroquinazolin-2(1H)-one	non-polymer		162.2	3	Chemie (3PF)
3	E, F, J, K (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
4	G, H, M (A, C)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
5	N, O, P (A, B, C)	water	water		18.0	342	Chemie (HOH)

Sequence modifications

A, B, C: 67 - 200 (UniProt: P25440)

PDB	External Database	Details
Gly 47	-	expression tag
Ser 48	-	expression tag
Ser 49	-	expression tag
His 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
Ser 56	-	expression tag
Ser 57	-	expression tag
Gly 58	-	expression tag
Leu 59	-	expression tag
Val 60	-	expression tag
Pro 61	-	expression tag
Arg 62	-	expression tag
Gly 63	-	expression tag
Ser 64	-	expression tag
His 65	-	expression tag
Met 66	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	53726.2
Non-Polymers*	Number of molecules	10
	Total formula weight	1023.0
All*	Total formula weight	54749.2

*Water molecules are not included.