4A6E
Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM and N-acetylserotonin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HYDROXYINDOLE O-METHYLTRANSFERASE | polymer | 353 | 39478.8 | 1 | UniProt (P46597) Pfam (PF00891) | HOMO SAPIENS (HUMAN) | N-ACETYL SEROTONIN METHYLTRANSFERASE, HIOMT, ACETYLSEROTONIN O-METHYLTRANSFERASE, ASMT |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 4 | D (A) | N-ACETYL SEROTONIN | non-polymer | 218.3 | 1 | Chemie (ASE) | |||
| 5 | E, F, G, H, I... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 6 | K (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | L (A) | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A: 1 - 346 (UniProt: P46597)
| PDB | External Database | Details |
|---|---|---|
| Thr 347 | - | expression tag |
| His 348 | - | expression tag |
| His 349 | - | expression tag |
| His 350 | - | expression tag |
| His 351 | - | expression tag |
| His 352 | - | expression tag |
| His 353 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39478.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1350.6 | |
| All* | Total formula weight | 40829.4 |
