4A6E
Crystal structure of human N-acetylserotonin methyltransferase (ASMT) in complex with SAM and N-acetylserotonin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HYDROXYINDOLE O-METHYLTRANSFERASE | polymer | 353 | 39478.8 | 1 | UniProt (P46597) Pfam (PF08100) Pfam (PF00891) | HOMO SAPIENS (HUMAN) | N-ACETYL SEROTONIN METHYLTRANSFERASE, HIOMT, ACETYLSEROTONIN O-METHYLTRANSFERASE, ASMT |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (9865603) PubChem (12312798) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (145712080) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 4 | D (A) | N-ACETYL SEROTONIN | non-polymer | 218.3 | 1 | Chemie (ASE) | |||
| 5 | E, F, G, H, I... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 6 | K (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 7 | L (A) | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A: 1 - 346 (UniProt: P46597)
| PDB | External Database | Details |
|---|---|---|
| Thr 347 | - | expression tag |
| His 348 | - | expression tag |
| His 349 | - | expression tag |
| His 350 | - | expression tag |
| His 351 | - | expression tag |
| His 352 | - | expression tag |
| His 353 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39478.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1350.6 | |
| All* | Total formula weight | 40829.4 |
