4A4B
Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | E3 UBIQUITIN-PROTEIN LIGASE CBL | polymer | 391 | 45136.8 | 1 | UniProt (P22681) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) Pfam (PF00097) In PDB | HOMO SAPIENS (HUMAN) | CASITAS B-LINEAGE LYMPHOMA PROTO-ONCOGENE, PROTO-ONCOGENE C-CBL, RING FINGER PROTEIN 55, SIGNAL TRANSDUCTION PROTEIN CBL, C-CBL |
| 2 | B | TYROSINE-PROTEIN KINASE ZAP-70 | polymer | 12 | 1344.3 | 1 | UniProt (P43403) In PDB | HOMO SAPIENS | 70 KDA ZETA-ASSOCIATED PROTEIN, SYK-RELATED TYROSINE KINASE, ZAP-70 |
| 3 | C | UBIQUITIN-CONJUGATING ENZYME E2 D2 | polymer | 147 | 16755.2 | 1 | UniProt (P62837) Pfam (PF00179) In PDB | HOMO SAPIENS (HUMAN) | UBIQUITIN CARRIER PROTEIN D2, UBIQUITIN-CONJUGATING ENZYME E2(17)KB 2, UBIQUITIN-CONJUGATING ENZYME E2-17 KDA 2, UBIQUITIN-PROTEIN LIGASE D2, UBCH5B |
| 4 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A: 47 - 435 (UniProt: P22681)
| PDB | External Database | Details |
|---|---|---|
| Gly 45 | - | expression tag |
| Ser 46 | - | expression tag |
| Phe 368 | Tyr 368 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 63236.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 170.9 | |
| All* | Total formula weight | 63407.2 |
