4A2L
Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | TWO-COMPONENT SYSTEM SENSOR HISTIDINE KINASE/RESPONSE | polymer | 795 | 90525.3 | 6 | UniProt (Q89YR8) Pfam (PF07494) Pfam (PF07495) | BACTEROIDES THETAIOTAOMICRON | BT_4663 |
| 2 | EA, G, H, HA, M (E, A, F, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 5 | Chemie (PGE) | |||
| 3 | I, N, O, S, Z (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | BA, DA, IA, J, K... (D, E, F, A, B...) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 11 | Chemie (PEG) | |||
| 5 | L (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 6 | CA, GA, P (D, E, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 3 | Chemie (MES) | |||
| 7 | FA, U, V (E, C) | OXALOACETATE ION | non-polymer | 131.1 | 3 | Chemie (OAA) | |||
| 8 | AA (D) | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 1 | Chemie (2PE) | |||
| 9 | JA, KA, LA, MA, NA... (A, B, C, D, E...) | water | water | 18.0 | 301 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 787 (UniProt: Q89YR8)
| PDB | External Database | Details |
|---|---|---|
| Leu 788 | - | expression tag |
| Glu 789 | - | expression tag |
| His 790 | - | expression tag |
| His 791 | - | expression tag |
| His 792 | - | expression tag |
| His 793 | - | expression tag |
| His 794 | - | expression tag |
| His 795 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 543151.5 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 3816.1 | |
| All* | Total formula weight | 546967.6 |
