4A2L

Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	TWO-COMPONENT SYSTEM SENSOR HISTIDINE KINASE/RESPONSE	polymer	795	90525.3	6	UniProt (Q89YR8) Pfam (PF07494) Pfam (PF07495) In PDB	BACTEROIDES THETAIOTAOMICRON	BT_4663
2	E, A, F, B	TRIETHYLENE GLYCOL	non-polymer		150.2	5	Chemie (PGE)
3	A, B, C, D	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
4	D, E, F, A, B...	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	11	Chemie (PEG)
5	B	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
6	D, E, B	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	3	Chemie (MES)
7	E, C	OXALOACETATE ION	non-polymer		131.1	3	Chemie (OAA)
8	D	NONAETHYLENE GLYCOL	non-polymer		414.5	1	Chemie (2PE)
9		water	water		18.0	301	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 787 (UniProt: Q89YR8)

PDB	External Database	Details
Leu 788	-	expression tag
Glu 789	-	expression tag
His 790	-	expression tag
His 791	-	expression tag
His 792	-	expression tag
His 793	-	expression tag
His 794	-	expression tag
His 795	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	543151.5
Non-Polymers*	Number of molecules	29
	Total formula weight	3816.1
All*	Total formula weight	546967.6

*Water molecules are not included.