4A2L

Structure of the periplasmic domain of the heparin and heparan sulphate sensing hybrid two component system BT4663 in apo and ligand bound forms

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE A 1785

Chain	Residue
A	ARG598
A	ARG618
A	LEU660
A	ASP662

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE A 1786

Chain	Residue
F	HOH2048
A	ARG656
A	LEU659
F	GLY754
F	THR755
F	VAL780

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 1787

Chain	Residue
A	SER272

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 1788

Chain	Residue
A	TYR739
A	LYS761

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG B 1784

Chain	Residue
B	SER272

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PG4 B 1785

Chain	Residue
B	LEU660
B	ASP662

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE B 1786

Chain	Residue
B	TRP737
B	TYR739
B	LYS761
B	TRP769

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MES B 1789

Chain	Residue
A	ASN375
A	ASN407
A	LYS409
A	HIS425
B	ARG266
B	PHE281
B	SER311
B	ARG313
B	TYR328

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG C 1784

Chain	Residue
E	SER168

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG C 1785

Chain	Residue
C	SER552
C	GLU593
C	ASP594
C	ARG638
C	HOH2055

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 1786

Chain	Residue
C	SER520
C	VAL521
C	LYS531
C	SER533
C	ILE534
C	LEU535

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG C 1787

Chain	Residue
C	ASP460
C	GLY461
C	ARG505
C	HIS508
C	LYS509
C	GLN524

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OAA C 1788

Chain	Residue
C	ARG618
C	SER765
C	ASP766
C	OAA1789

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OAA C 1789

Chain	Residue
C	TYR739
C	TRP769
C	OAA1788

---

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG D 1784

Chain	Residue
D	ARG505

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG D 1785

Chain	Residue
D	GLU364
D	ASP365
D	SER640

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 1787

Chain	Residue
D	SER272
D	SER319
D	TYR665

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 2PE D 1788

Chain	Residue
D	ARG598
D	ARG618
D	LEU660
D	ASP662

---

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG D 1789

Chain	Residue
D	SER166

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MES D 1790

Chain	Residue
C	ASN375
D	ARG266
D	PHE281
D	ARG310
D	SER311
D	ARG313

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG E 1784

Chain	Residue
E	LYS366
E	SER640

---

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGE E 1785

Chain	Residue
E	ARG638

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OAA E 1786

Chain	Residue
E	SER272
E	MET317
E	SER319
E	TYR665

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MES E 1787

Chain	Residue
E	ARG266
E	PHE281
E	SER311
E	ARG313
E	TYR328
F	HIS425

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE F 1784

Chain	Residue
F	TRP737
F	TYR739
F	LYS761
F	TRP769

---

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG F 1785

Chain	Residue
F	ARG618
F	SER765
F	ASP766

---