4A0C

Structure of the CAND1-CUL4B-RBX1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1	polymer	1253	139226.3	2	UniProt (Q86VP6) Pfam (PF13513) Pfam (PF08623) In PDB	HOMO SAPIENS (HUMAN)	CULLIN-ASSOCIATED AND NEDDYLATION-DISSOCIATED PROTEIN 1, TBP-INTERACTING PROTEIN OF 120 KDA A, TBP-INTERACTING PROTEIN 120A, P120 CAND1
2	C, E	CULLIN-4B	polymer	741	86961.3	2	UniProt (Q13620) Pfam (PF00888) Pfam (PF10557) In PDB	HOMO SAPIENS (HUMAN)	CUL-4B
3	D, F	E3 UBIQUITIN-PROTEIN LIGASE RBX1	polymer	98	11330.9	2	UniProt (P62878) Pfam (PF12678) In PDB	MUS MUSCULUS (HOUSE MOUSE)	RING FINGER PROTEIN 75, RING-BOX PROTEIN 1, RBX1
4	D, F	ZINC ION	non-polymer		65.4	6	Chemie (ZN)

Sequence modifications

A, B: 1 - 1230 (UniProt: Q86VP6)

PDB	External Database	Details
Met -22	-	expression tag
Ala -21	-	expression tag
Ser -20	-	expression tag
Trp -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
Pro -16	-	expression tag
Gln -15	-	expression tag
Phe -14	-	expression tag
Glu -13	-	expression tag
Lys -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Glu -9	-	expression tag
Asn -8	-	expression tag
Leu -7	-	expression tag
Tyr -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag
Val 952	Ala 952	variant

C, E: 192 - 913 (UniProt: Q13620)

PDB	External Database	Details
Met 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag
His 179	-	expression tag
Val 180	-	expression tag
Asp 181	-	expression tag
Glu 182	-	expression tag
Asn 183	-	expression tag
Leu 184	-	expression tag
Tyr 185	-	expression tag
Phe 186	-	expression tag
Gln 187	-	expression tag
Gly 188	-	expression tag
Gly 189	-	expression tag
Gly 190	-	expression tag
Arg 191	-	expression tag

D, F: 12 - 108 (UniProt: P62878)

PDB	External Database	Details
Met 11	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	475037.1
Non-Polymers*	Number of molecules	6
	Total formula weight	392.5
All*	Total formula weight	475429.6

*Water molecules are not included.