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4A0C

Structure of the CAND1-CUL4B-RBX1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000151cellular_componentubiquitin ligase complex
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0010265biological_processSCF complex assembly
A0016020cellular_componentmembrane
A0016567biological_processprotein ubiquitination
A0017025molecular_functionTBP-class protein binding
A0030154biological_processcell differentiation
A0031461cellular_componentcullin-RING ubiquitin ligase complex
A0034774cellular_componentsecretory granule lumen
A0043086biological_processnegative regulation of catalytic activity
A0045893biological_processpositive regulation of DNA-templated transcription
A0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
A0070062cellular_componentextracellular exosome
A1904813cellular_componentficolin-1-rich granule lumen
B0000151cellular_componentubiquitin ligase complex
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0010265biological_processSCF complex assembly
B0016020cellular_componentmembrane
B0016567biological_processprotein ubiquitination
B0017025molecular_functionTBP-class protein binding
B0030154biological_processcell differentiation
B0031461cellular_componentcullin-RING ubiquitin ligase complex
B0034774cellular_componentsecretory granule lumen
B0043086biological_processnegative regulation of catalytic activity
B0045893biological_processpositive regulation of DNA-templated transcription
B0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
B0070062cellular_componentextracellular exosome
B1904813cellular_componentficolin-1-rich granule lumen
C0006511biological_processubiquitin-dependent protein catabolic process
C0031461cellular_componentcullin-RING ubiquitin ligase complex
C0031625molecular_functionubiquitin protein ligase binding
D0000151cellular_componentubiquitin ligase complex
D0000209biological_processprotein polyubiquitination
D0004842molecular_functionubiquitin-protein transferase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005680cellular_componentanaphase-promoting complex
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006281biological_processDNA repair
D0006283biological_processtranscription-coupled nucleotide-excision repair
D0006511biological_processubiquitin-dependent protein catabolic process
D0006513biological_processprotein monoubiquitination
D0006974biological_processDNA damage response
D0007283biological_processspermatogenesis
D0008190molecular_functioneukaryotic initiation factor 4E binding
D0008270molecular_functionzinc ion binding
D0016567biological_processprotein ubiquitination
D0016740molecular_functiontransferase activity
D0019005cellular_componentSCF ubiquitin ligase complex
D0030163biological_processprotein catabolic process
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031461cellular_componentcullin-RING ubiquitin ligase complex
D0031462cellular_componentCul2-RING ubiquitin ligase complex
D0031463cellular_componentCul3-RING ubiquitin ligase complex
D0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
D0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
D0031466cellular_componentCul5-RING ubiquitin ligase complex
D0031467cellular_componentCul7-RING ubiquitin ligase complex
D0031625molecular_functionubiquitin protein ligase binding
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032480biological_processnegative regulation of type I interferon production
D0034450molecular_functionubiquitin-ubiquitin ligase activity
D0034599biological_processcellular response to oxidative stress
D0034644biological_processcellular response to UV
D0042110biological_processT cell activation
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0045116biological_processprotein neddylation
D0045732biological_processpositive regulation of protein catabolic process
D0046627biological_processnegative regulation of insulin receptor signaling pathway
D0046872molecular_functionmetal ion binding
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0061630molecular_functionubiquitin protein ligase activity
D0061663molecular_functionNEDD8 ligase activity
D0070936biological_processprotein K48-linked ubiquitination
D0071230biological_processcellular response to amino acid stimulus
D0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
D0097602molecular_functioncullin family protein binding
D0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D0160240biological_processRNA polymerase II transcription initiation surveillance
D1902499biological_processpositive regulation of protein autoubiquitination
D1902883biological_processnegative regulation of response to oxidative stress
D1904263biological_processpositive regulation of TORC1 signaling
E0006511biological_processubiquitin-dependent protein catabolic process
E0031461cellular_componentcullin-RING ubiquitin ligase complex
E0031625molecular_functionubiquitin protein ligase binding
F0000151cellular_componentubiquitin ligase complex
F0000209biological_processprotein polyubiquitination
F0004842molecular_functionubiquitin-protein transferase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005680cellular_componentanaphase-promoting complex
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006281biological_processDNA repair
F0006283biological_processtranscription-coupled nucleotide-excision repair
F0006511biological_processubiquitin-dependent protein catabolic process
F0006513biological_processprotein monoubiquitination
F0006974biological_processDNA damage response
F0007283biological_processspermatogenesis
F0008190molecular_functioneukaryotic initiation factor 4E binding
F0008270molecular_functionzinc ion binding
F0016567biological_processprotein ubiquitination
F0016740molecular_functiontransferase activity
F0019005cellular_componentSCF ubiquitin ligase complex
F0030163biological_processprotein catabolic process
F0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
F0031461cellular_componentcullin-RING ubiquitin ligase complex
F0031462cellular_componentCul2-RING ubiquitin ligase complex
F0031463cellular_componentCul3-RING ubiquitin ligase complex
F0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
F0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
F0031466cellular_componentCul5-RING ubiquitin ligase complex
F0031467cellular_componentCul7-RING ubiquitin ligase complex
F0031625molecular_functionubiquitin protein ligase binding
F0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
F0032480biological_processnegative regulation of type I interferon production
F0034450molecular_functionubiquitin-ubiquitin ligase activity
F0034599biological_processcellular response to oxidative stress
F0034644biological_processcellular response to UV
F0042110biological_processT cell activation
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0045116biological_processprotein neddylation
F0045732biological_processpositive regulation of protein catabolic process
F0046627biological_processnegative regulation of insulin receptor signaling pathway
F0046872molecular_functionmetal ion binding
F0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
F0061630molecular_functionubiquitin protein ligase activity
F0061663molecular_functionNEDD8 ligase activity
F0070936biological_processprotein K48-linked ubiquitination
F0071230biological_processcellular response to amino acid stimulus
F0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
F0097602molecular_functioncullin family protein binding
F0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
F0160240biological_processRNA polymerase II transcription initiation surveillance
F1902499biological_processpositive regulation of protein autoubiquitination
F1902883biological_processnegative regulation of response to oxidative stress
F1904263biological_processpositive regulation of TORC1 signaling
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 4001
ChainResidue
DCYS42
DCYS45
DHIS80
DCYS83

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 4002
ChainResidue
DCYS75
DHIS77
DCYS94
DASP97

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 4003
ChainResidue
DCYS56
DCYS68
DHIS82
DCYS53

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 4001
ChainResidue
FCYS42
FCYS45
FHIS80
FCYS83

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 4002
ChainResidue
FCYS75
FHIS77
FCYS94
FASP97

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 4003
ChainResidue
FCYS53
FCYS56
FCYS68
FHIS82

Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. LKkrIesLIDRdYMeRdkenpnqYnYiA
ChainResidueDetails
CLEU886-ALA913

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues90
DetailsZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
ChainResidueDetails
DCYS53-ASN98
FCYS53-ASN98

site_idSWS_FT_FI2
Number of Residues22
DetailsBINDING: BINDING => ECO:0000269|PubMed:22118460
ChainResidueDetails
DCYS42
DCYS94
DASP97
FCYS42
FCYS45
FCYS53
FCYS56
FCYS68
FCYS75
FHIS77
FHIS80
DCYS45
FHIS82
FCYS94
FASP97
DCYS53
DCYS56
DCYS68
DCYS75
DHIS77
DHIS80
DHIS82

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62877
ChainResidueDetails
DCYS83
FCYS83

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER558
BSER558

237423

PDB entries from 2025-06-11

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