3ZRB
Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROGESTERONE RECEPTOR | polymer | 260 | 29968.1 | 2 | UniProt (P06401) Pfam (PF00104) | HOMO SAPIENS (HUMAN) | PR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 3 |
| 2 | C (A) | 2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE | non-polymer | 394.9 | 1 | Chemie (OR8) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | E, F, G, I (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | H (B) | (R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE | non-polymer | 375.4 | 1 | Chemie (ORC) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 226 | Chemie (HOH) |
Sequence modifications
A, B: 678 - 933 (UniProt: P06401)
| PDB | External Database | Details |
|---|---|---|
| Gly 674 | - | expression tag |
| Ser 675 | - | expression tag |
| His 676 | - | expression tag |
| Met 677 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59936.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1234.8 | |
| All* | Total formula weight | 61171.0 |
