3ZKP

Structure of a mutant of P450 EryK in complex with erythromycin B.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ERYTHROMYCIN C-12 HYDROXYLASE	polymer	411	45286.9	1	UniProt (P48635) Pfam (PF00067) In PDB	SACCHAROPOLYSPORA ERYTHRAEA NRRL 2338	CYTOCHROME P450 113A1, ERYK, CYP113A1, ERYTHROMYCIN D C-12 HYDROXYLASE
2	A	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	1	Chemie (HEM)
3	A	Erythromycin B	non-polymer		717.9	1	Chemie (ERB)
4		water	water		18.0	329	Chemie (HOH)

Sequence modifications

A: 16 - 411 (UniProt: P48635)

PDB	External Database	Details
Met 1	-	SEE REMARK 999
Phe 2	-	SEE REMARK 999
Ala 3	-	SEE REMARK 999
Asp 4	-	SEE REMARK 999
Val 5	-	SEE REMARK 999
Glu 6	-	SEE REMARK 999
Thr 7	-	SEE REMARK 999
Thr 8	-	SEE REMARK 999
Cys 9	-	SEE REMARK 999
Cys 10	-	SEE REMARK 999
Ala 11	-	SEE REMARK 999
Arg 12	-	SEE REMARK 999
Arg 13	-	SEE REMARK 999
Thr 14	-	SEE REMARK 999
Leu 15	-	SEE REMARK 999
Ala 86	Met 72	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	45286.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1334.4
All*	Total formula weight	46621.3

*Water molecules are not included.