3ZKN
BACE2 FAB INHIBITOR COMPLEX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | BETA-SECRETASE 2 | polymer | 386 | 42105.4 | 2 | UniProt (Q9Y5Z0) Pfam (PF00026) In PDB | HOMO SAPIENS | BACE2, ASPARTIC-LIKE PROTEASE 56 KDA, ASPARTYL PROTEASE 1, ASP1, ASP 1, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2, BETA-SITE APP CLEAVING ENZYME 2, DOWN REGION ASPARTIC PROTEASE, DRAP, MEMAPSIN-1, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 1, THETA-SECRETASE |
| 2 | C, H | FAB HEAVY CHAIN | polymer | 221 | 23671.7 | 2 | MUS MUSCULUS (HOUSE MOUSE) | ||
| 3 | D, L | FAB LIGHT CHAIN | polymer | 218 | 23924.3 | 2 | MUS MUSCULUS (HOUSE MOUSE) | ||
| 4 | A, B | 5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((S)-2-amino-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-4-yl)-phenyl]-amide | non-polymer | 435.4 | 2 | Chemie (WZV) | |||
| 5 | A, B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 6 | A, B, C, H | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 7 | C, H | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | water | water | 18.0 | 842 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 179402.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1787.6 | |
| All* | Total formula weight | 181190.4 |
