Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE WZV A 1398 |
| Chain | Residue |
| A | ASP48 |
| A | TYR87 |
| A | GLN89 |
| A | ASN123 |
| A | LEU126 |
| A | ILE134 |
| A | ASP241 |
| A | THR244 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 1399 |
| Chain | Residue |
| A | CYS282 |
| A | TRP283 |
| A | GLN279 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1400 |
| Chain | Residue |
| A | GLU98 |
| A | LEU112 |
| A | VAL113 |
| A | ASN114 |
| A | GLU150 |
| A | SER155 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1401 |
| Chain | Residue |
| A | THR88 |
| A | ARG248 |
| A | SER339 |
| A | THR340 |
| A | ASN341 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE WZV B 1398 |
| Chain | Residue |
| B | ASP48 |
| B | GLN89 |
| B | ASN123 |
| B | LEU126 |
| B | ILE134 |
| B | ASP241 |
| B | THR244 |
| B | HOH2161 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS B 1399 |
| Chain | Residue |
| B | GLN279 |
| B | CYS282 |
| B | TRP283 |
| B | HOH2125 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1400 |
| Chain | Residue |
| B | GLU98 |
| B | LEU112 |
| B | VAL113 |
| B | ASN114 |
| B | GLU150 |
| B | SER155 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1401 |
| Chain | Residue |
| B | THR88 |
| B | ARG248 |
| B | SER339 |
| B | THR340 |
| B | ASN341 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1217 |
| Chain | Residue |
| C | PRO192 |
| C | SER193 |
| C | SER195 |
| C | LYS212 |
| C | HOH2126 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 1218 |
| Chain | Residue |
| C | ARG38 |
| C | LYS43 |
| C | GLU46 |
| C | ALA62 |
| C | PHE63 |
| C | ARG66 |
| C | HOH2025 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 H 1217 |
| Chain | Residue |
| H | SER193 |
| H | SER195 |
| H | LYS212 |
| H | HOH2121 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL H 1218 |
| Chain | Residue |
| H | ARG38 |
| H | LYS43 |
| H | GLU46 |
| H | ALA62 |
| H | PHE63 |
| H | ARG66 |
| H | HOH2020 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE45-VAL56 | |
| A | ALA238-LEU249 | |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| D | TYR196-HIS202 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | ASP48 | |
| A | ASP241 | |
| B | ASP48 | |
| B | ASP241 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN108 | |
| A | ASN304 | |
| B | ASN108 | |
| B | ASN304 | |
