3ZKG
BACE2 MUTANT APO STRUCTURE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | BETA-SECRETASE 2 | polymer | 386 | 42047.4 | 2 | UniProt (Q9Y5Z0) Pfam (PF00026) | HOMO SAPIENS (HUMAN) | ASPARTIC-LIKE PROTEASE 56 KDA, ASPARTYL PROTEASE 1, ASP1, ASP 1, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2, BETA-SITE APP CLEAVING ENZYME 2, DOWN REGION ASPARTIC PROTEASE, DRAP, MEMAPSIN-1, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 1, THETA-SECRETASE, BACE2 |
| 2 | C (A) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) PubChem (125132) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A, B: 13 - 398 (UniProt: Q9Y5Z0)
| PDB | External Database | Details |
|---|---|---|
| Ala 269 | Glu 331 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84094.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 282.3 | |
| All* | Total formula weight | 84377.0 |
