3ZGV
Structure of human SIRT2 in complex with ADP-ribose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 | polymer | 325 | 36676.2 | 2 | UniProt (Q8IXJ6) Pfam (PF02146) | HOMO SAPIENS (HUMAN) | SIRTUIN 2, ISOFORM 1, REGULATORY PROTEIN SIR2 HOMOLOG 2, SIR2-LIKE PROTEIN 2 |
| 2 | C, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F, G, H, J... (A, B) | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) | |||
| 4 | E, K (A, B) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 2 | Chemie (AR6) | |||
| 5 | M (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | N (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 7 | O, P (A, B) | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
A, B: 34 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| Gly 32 | - | expression tag |
| Ser 33 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73352.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1846.0 | |
| All* | Total formula weight | 75198.3 |
