3ZGV
Structure of human SIRT2 in complex with ADP-ribose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 | polymer | 325 | 36676.2 | 2 | UniProt (Q8IXJ6) Pfam (PF02146) | HOMO SAPIENS (HUMAN) | SIRTUIN 2, ISOFORM 1, REGULATORY PROTEIN SIR2 HOMOLOG 2, SIR2-LIKE PROTEIN 2 |
| 2 | C, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F, G, H, J... (A, B) | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) PubChem (175) | |||
| 4 | E, K (A, B) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 2 | Chemie (AR6) PubChem (192) PubChem (25113622) PubChem (25113623) PubChem (44415180) PubChem (51051599) PubChem (44144391) PubChem (445794) PubChem (447048) PubChem (89379870) PubChem (33576) PubChem (447165) PubChem (448826) PubChem (91746164) PubChem (9548001) PubChem (9547960) PubChem (122606931) PubChem (122609061) PubChem (10437766) PubChem (174159053) PubChem (140853820) PubChem (146879505) PubChem (162774256) PubChem (162782217) PubChem (163972867) PubChem (173750345) PubChem (173750346) PubChem (175675949) | |||
| 5 | M (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 6 | N (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 7 | O, P (A, B) | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
A, B: 34 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| Gly 32 | - | expression tag |
| Ser 33 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73352.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1846.0 | |
| All* | Total formula weight | 75198.3 |
