3ZGV
Structure of human SIRT2 in complex with ADP-ribose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 400 |
| Chain | Residue |
| A | CYS195 |
| A | CYS200 |
| A | CYS221 |
| A | CYS224 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 470 |
| Chain | Residue |
| A | PHE96 |
| A | HIS187 |
| A | VAL233 |
| A | AR6500 |
| A | HOH2068 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE AR6 A 500 |
| Chain | Residue |
| A | GLY84 |
| A | ALA85 |
| A | GLY86 |
| A | THR89 |
| A | ASP95 |
| A | PHE96 |
| A | ARG97 |
| A | TYR104 |
| A | GLN167 |
| A | HIS187 |
| A | PHE235 |
| A | GLY261 |
| A | THR262 |
| A | SER263 |
| A | VAL266 |
| A | ASN286 |
| A | LYS287 |
| A | GLU288 |
| A | GLY322 |
| A | GLU323 |
| A | CYS324 |
| A | ACT470 |
| A | HOH2023 |
| A | HOH2034 |
| A | HOH2105 |
| A | HOH2141 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 1000 |
| Chain | Residue |
| A | LEU321 |
| A | HOH2138 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 1001 |
| Chain | Residue |
| A | ARG97 |
| A | GLU116 |
| A | GLN265 |
| A | HOH2107 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 1002 |
| Chain | Residue |
| A | SER293 |
| A | MET299 |
| A | GLY304 |
| A | GLY306 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 400 |
| Chain | Residue |
| B | CYS195 |
| B | CYS200 |
| B | CYS221 |
| B | CYS224 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 470 |
| Chain | Residue |
| B | ILE169 |
| B | HIS187 |
| B | VAL233 |
| B | AR6500 |
| site_id | AC9 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE AR6 B 500 |
| Chain | Residue |
| B | GLY84 |
| B | ALA85 |
| B | GLY86 |
| B | THR89 |
| B | ASP95 |
| B | PHE96 |
| B | ARG97 |
| B | TYR104 |
| B | GLN167 |
| B | HIS187 |
| B | PHE235 |
| B | GLY261 |
| B | THR262 |
| B | SER263 |
| B | VAL266 |
| B | ASN286 |
| B | LYS287 |
| B | GLU288 |
| B | GLY322 |
| B | GLU323 |
| B | CYS324 |
| B | ACT470 |
| B | HOH2017 |
| B | HOH2049 |
| B | HOH2083 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT B 1000 |
| Chain | Residue |
| B | GOL1357 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1357 |
| Chain | Residue |
| A | HOH2046 |
| B | GLU116 |
| B | ACT1000 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGE B 1358 |
| Chain | Residue |
| B | GLY291 |
| B | SER293 |
| B | PRO295 |
| B | MET299 |
| B | MET301 |
| B | LEU303 |
| B | GLY304 |
| B | HOH2103 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RMG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11427894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23454361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24389023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25704306","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R8M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RJQ4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
